Of course, however, the range of your attacks is critical.
My little toads from the Witch Doctor don't go very far, but the DH and Wizard have spells that go across a screen.
Well, yes, hold shift all by itself doesn't do anything. You're just holding the shift key which holds the character in place. You have to click the attack to do anything. I don't actually understand the problem with this.
Ahhhh but you want to attack too? Or just run away, screaming wildly? If you target and hit attack you will launch your attack. If you want untargeted attack, you must use shift, then the attack goes wherever your pointer is. If that makes sense.
It's my Demon Hunter's normal mode, not so much with the Witch Doctor or Wizard, they only do that with explosive bosses or champs.