There is nothing at all random about the genome that makes humans -- it was selected for by natural pressures over eons. But that is also (unlike someone else mentioned above) not "designed." Designed always implies a designer. Yet, it is a fact that had anything about the environment(s) in which we evolved been different, we would be different. A change in climate, an earthquake, the development of a mountain, formation of a desert are not done by any agency -- they simply happen. And as they happen, they have an impact on how all organisms affected by them evolve.