Drug designed to treat COVID-19 could help people heal from virus, researchers claim

[We Never Know]

Sometimes information is information, eg, the OP in this thread.
Sometimes it's misleading, eg, pushing Ivermectin as Covid treatment.

Yeah...cuz that's what it means when employers
require employees to get vaccinated. Oh, brother.

I don't know all the companies in my portfolio.
Delta & CVS are there. I think Ford was sold.
Others....I haven't a clue.

I don't shuffle mine much. However I did have a lot in TLRY & OGI that I bought in Jan but sold them all in March before they dropped. Made a very good profit.

 

[ADigitalArtist]

Just out yesterday....

Having SARS-CoV-2 once confers much greater immunity than a vaccine—but no infection parties, please

The natural immune protection that develops after a SARS-CoV-2 infection offers considerably more of a shield against the Delta variant of the pandemic coronavirus than two doses of the Pfizer-BioNTech vaccine, according to a large Israeli study that some scientists wish came with a “Don’t try this at home” label. The newly released data show people who once had a SARS-CoV-2 infection were much less likely than vaccinated people to get Delta, develop symptoms from it, or become hospitalized with serious COVID-19.

Having SARS-CoV-2 once confers much greater immunity than a vaccine—but no infection parties, please

The article linked to in your link comes to a not peer reviewed preprint. And even it says

Individuals who were both previously infected with SARS-CoV-2 and given a single dose of the vaccine gained additional protection against the Delta variant.

So basically both vaccinated and unvaccinated should have a booster.

 

[We Never Know]

The article linked to in your link comes to a not peer reviewed preprint. And even it says
So basically both vaccinated and unvaccinated should have a booster.

Its not a cure, its a potential treatment. The Dr still recommends the vax

"Dr. Liu explained he is hopeful that a combination of the vaccine, Remdesivir and MPI8 will be highly effective together in keeping people from getting sick and dying from the virus."

 

[ADigitalArtist]

Its not a cure, its a potential treatment. The Dr still recommends the vax

"Dr. Liu explained he is hopeful that a combination of the vaccine, Remdesivir and MPI8 will be highly effective together in keeping people from getting sick and dying from the virus."

I was just talking about the article linked in the last post. Not the conservative US's weird fixation with snake oil even the manufacturers keep telling them isn't effective.

 

[We Never Know]

The article linked to in your link comes to a not peer reviewed preprint. And even it says
So basically both vaccinated and unvaccinated should have a booster.

MPI8 is Potent against SARS-CoV-2 by Inhibiting Dually and Selectively the SARS-CoV-2 Main Protease and the Host Cathepsin L*

Abstract
A number of inhibitors have been developed for the SARS-CoV-2 main protease (MPro ) as potential COVID-19 medications but little is known about their selectivity. Using enzymatic assays, we characterized inhibition of TMPRSS2, furin, and cathepsins B/K/L by more than a dozen of previously developed MPro inhibitors including MPI1-9, GC376, 11a, 10-1, 10-2, and 10-3. MPI1-9, GC376 and 11a all contain an aldehyde for the formation of a reversible covalent hemiacetal adduct with the MPro active site cysteine and 10-1, 10-2 and 10-3 contain a labile ester to exchange with the MPro active site cysteine for the formation of a thioester. Our data revealed that all these inhibitors are inert toward TMPRSS2 and furin. Diaryl esters also showed low inhibition of cathepsins. However, all aldehyde inhibitors displayed high potency in inhibiting three cathepsins. Their determined IC50 values vary from 4.1 to 380 nM for cathepsin B, 0.079 to 2.3 nM for cathepsin L, and 0.35 to 180 nM for cathepsin K. All aldehyde inhibitors showed similar inhibition levels toward cathepsin L. A cellular analysis indicated high potency of MPI5 and MPI8 in inhibiting lysosomal activity, which is probably attributed to their inhibition of cathepsins. Among all aldehyde inhibitors, MPI8 shows the best selectivity toward cathepsin L. With respect to cathepsins B and K, the selective indices are 192 and 150, respectively. MPI8 is the most potent compound among all aldehyde inhibitors in cellular MPro inhibition potency and anti-SARS-CoV-2 activity in Vero E6 cells. Cathepsin L has been demonstrated to play a critical role in the SARS-CoV-2 cell entry. By selectively inhibiting both SARS-CoV-2 MPro and the host cathepsin L, MPI8 potentiates dual inhibition effects to synergize its overall antiviral potency and efficacy. Due to its high selectivity toward cathepsin L that reduces potential toxicity toward host cells and high cellular and antiviral potency, we urge serious consideration of MPI8 for preclinical and clinical investigations for treating COVID-19.

MPI8 is Potent against SARS-CoV-2 by Inhibiting Dually and Selectively the SARS-CoV-2 Main Protease and the Host Cathepsin L* - PubMed

 

[ADigitalArtist]

MPI8 is Potent against SARS-CoV-2 by Inhibiting Dually and Selectively the SARS-CoV-2 Main Protease and the Host Cathepsin L*

Abstract
A number of inhibitors have been developed for the SARS-CoV-2 main protease (MPro ) as potential COVID-19 medications but little is known about their selectivity. Using enzymatic assays, we characterized inhibition of TMPRSS2, furin, and cathepsins B/K/L by more than a dozen of previously developed MPro inhibitors including MPI1-9, GC376, 11a, 10-1, 10-2, and 10-3. MPI1-9, GC376 and 11a all contain an aldehyde for the formation of a reversible covalent hemiacetal adduct with the MPro active site cysteine and 10-1, 10-2 and 10-3 contain a labile ester to exchange with the MPro active site cysteine for the formation of a thioester. Our data revealed that all these inhibitors are inert toward TMPRSS2 and furin. Diaryl esters also showed low inhibition of cathepsins. However, all aldehyde inhibitors displayed high potency in inhibiting three cathepsins. Their determined IC50 values vary from 4.1 to 380 nM for cathepsin B, 0.079 to 2.3 nM for cathepsin L, and 0.35 to 180 nM for cathepsin K. All aldehyde inhibitors showed similar inhibition levels toward cathepsin L. A cellular analysis indicated high potency of MPI5 and MPI8 in inhibiting lysosomal activity, which is probably attributed to their inhibition of cathepsins. Among all aldehyde inhibitors, MPI8 shows the best selectivity toward cathepsin L. With respect to cathepsins B and K, the selective indices are 192 and 150, respectively. MPI8 is the most potent compound among all aldehyde inhibitors in cellular MPro inhibition potency and anti-SARS-CoV-2 activity in Vero E6 cells. Cathepsin L has been demonstrated to play a critical role in the SARS-CoV-2 cell entry. By selectively inhibiting both SARS-CoV-2 MPro and the host cathepsin L, MPI8 potentiates dual inhibition effects to synergize its overall antiviral potency and efficacy. Due to its high selectivity toward cathepsin L that reduces potential toxicity toward host cells and high cellular and antiviral potency, we urge serious consideration of MPI8 for preclinical and clinical investigations for treating COVID-19.

MPI8 is Potent against SARS-CoV-2 by Inhibiting Dually and Selectively the SARS-CoV-2 Main Protease and the Host Cathepsin L* - PubMed

New Policy Regarding Posting Misinformation About The Coronavirus

 

[We Never Know]

I was just talking about the article linked in the last post. Not the conservative US's weird fixation with snake oil even the manufacturers keep telling them isn't effective.

When I read something unless its from a off the chart conspiracy site, I share it.
People are free to research it or find other articles on it.

 

[ADigitalArtist]

When I read something unless its from a off the chart conspiracy site, I share it.
People are free to research it or find other articles on it.

People are free to research or find other articles on it. But that doesn't mean they're free to post them here. Even if it's not an 'off the chart conspiracy site.'

 

[We Never Know]

New Policy Regarding Posting Misinformation About The Coronavirus

Ncbi/nih/NIH gov isnt misinformation.

Like I said if people dont like the link I share feel free to research it.

This one is from ncbi/nih/nih/gov about the exact same thing.

MPI8 is Potent against SARS-CoV-2 by Inhibiting Dually and Selectively the SARS-CoV-2 Main Protease and the Host Cathepsin L* - PubMed

 

[exchemist]

Here's the article from the university Texas A&M Researcher: New Drug Could Be ‘Game Changer’ Against COVID-19

The paper itself Error - Cookies Turned Off - you might get hit with that error.
MPI8 is Potent against SARS-CoV-2 by Inhibiting Dually and Selectively the SARS-CoV-2 Main Protease and the Host Cathepsin L** is the title

Thanks, I‘ve found it now. A protease inhibitor.

Could be helpful. But no clinical or pre-clinical work yet. So it will be year or so before we know if it really works.

 

[We Never Know]

Thanks, I‘ve found it now. A protease inhibitor.

Could be helpful. But no clinical or pre-clinical work yet. So it will be year or so before we know if it really works.

Here's a good link that's explains it.

pubmed.ncbi.nlm.nih.gov

MPI8 is Potent against SARS-CoV-2 by Inhibiting Dually and Selectively the SARS-CoV-2 Main Protease and the Host Cathepsin L* - PubMed

 

[Revoltingest]

Thanks, I‘ve found it now. A protease inhibitor.

Could be helpful. But no clinical or pre-clinical work yet. So it will be year or so before we know if it really works.

Aye, that sums it up.
Interesting good news.
No misinformation.
Potential for future treatment.

 

[We Never Know]

Thanks, I‘ve found it now. A protease inhibitor.

Could be helpful. But no clinical or pre-clinical work yet. So it will be year or so before we know if it really works.

Yes. Its says that in the link(s)

""[Researchers] want to finish all of the clinical analysis by the end of spring so they can send it to FDA new drug approval request," Liu said. "So I would think next summer, if everything goes okay, it will be available."

 

[nPeace]

The vaccines are free.

So are Clinics. Yet some opt for a private doctor. Why? Is it because of a conspiracy theory, misinformation, or a personal choice for what they see as a better service, and overall care?
Do you have anything against persons making a personal choice? Do you think that any personal choice that does not involve making the one you made, must obviously be a bad choice?
Let's talk this through with some rational, and see if we can get to the bottom of the barrel, so to speak.

 

[nPeace]

Random Dr? I guess if the CDC said cut your finger off and your own personal Dr said no, you would still do it.

Things that that make you go
This vaccine to some people is, "Oh my god." However, not in the usual way that's expressed.
Seems like the new religion, with many clergy, at the pulpit.

 

[nPeace]

My plan is to stick with just vaccine protection.
But I'm lazy.

Ah... but why push others to be the same? What's behind that? That's what I am trying to figure out.

 

[Revoltingest]

So are Clinics. Yes some opt for a private doctor. Why? Is it because of a conspiracy theory, misinformation, or a personal choice for what they see as a better service, and overall care?
Do you have anything against persons making a personal choice? Do you think that any personal choice that does not involve making the one you made, must obviously be a bad choice?
Let's talk this through with some rational, and see if we can get to the bottom of the barrel, so to speak.

I'm a fan of personal choice subject to the libertarian maxim...
My right to swing my arms ends where my neighbor's nose begins.
I won't infect others.
They shouldn't infect me.

 

[Revoltingest]

Ah... but why push others to be the same? What's behind that? That's what I am trying to figure out.

Because it's good for them & everyone else.

 

[We Never Know]

Because it's good for them & everyone else.

Good for them. When even the science says more studies are needed to evaluate the saftey?


From ncbi.nlm.nih.gov/pmc May 2021


Conclusions and Future Directions
Vaccination is playing a central role in the SARS-CoV-2 pandemic, impeding new infections, while saving millions of lives. However, there is no denying the fact that it is only the starting point and there are still many issues to address, such as unraveling the virulence ability of SARS-CoV-2 and choosing suitable experimental models and designs for clinical trials, and more robust scientific evidence is needed to fully evaluate the safety and efficacy of COVID-19 vaccines.

An Updated Review of SARS-CoV-2 Vaccines and the Importance of Effective Vaccination Programs in Pandemic Times

 

[Revoltingest]

Good for them. When even the science says more studies are needed to evaluate the saftey?

Are you claiming that the vaccines are unsafe?
Straight answer, please.