Shermana
Heretic
There have been numerous comments focused on the report, some (as you requested) addressing specific issues with the minutiae of the argument, others assessing what the report as a whole sets out to (and does or does not) achieve. All you have done in response to these criticisms is give us a regular page count coupled to a complaint that no-one is addressing the issues. This thread has done your credibility no favours.
Okay, for the second link (And the single population issue question in the first):
As before, however, the honesty of their argument can be called into question.
Note first the subtle conflation of "deleterious or even lethal" with "diminishing returns". The latter means that successive epistatic mutations add less fitness than previous ones - not that they are "deleterious".
Second, the research revealing these diminishing returns is restricted to mutations conferring antibiotic resistance on bacteria, and a paper not cited by Ewert and co. points out that
I"m not quite sure where they demonstrate that it's only "diminishing returns' and not actually harmful mutations in question. "Less fitness" can mean "reduced fitness" because of those. So let's see an example of where it actually proves they are only discussing a slow-down of fitness as opposed to harmful mutations. As we know, most mutations that aren't begign/neutral are in fact, harmful/deleterious.
Quote:
... if mutations have additive effects on resistance, a mutation that confers complete resistance to an antibiotic will provide a small benefit in a genotype that already has a high level of antibiotic resistance and a large benefit in a genotype that has a low level of antibiotic resistance.
In other words, diminishing returns go with this particular territory and are not necessarily applicable elsewhere.
Okay, but I think it's missing the point that those mutations often have a delterious counter-effect, if I'm not mistaken.
As we can see here, "Compensatory" mutations happen enough in small populations (not so much in large) to compensate for deleterious ones: (Which doesn't necessarily mean anything about overall survivability necessarily)
Analysis of the fitness effect of compensatory mutations
And even here, in your favor we see that deleterious mutations in SOME studies do not necessarily get in the way of adaptation.
PLOS Computational Biology: From Bad to Good: Fitness Reversals and the Ascent of Deleterious Mutations
A similar sentiment is said by this website, (Which happens to support eugneics but that's another story) in that deleterious mutations will find themselves on the way out.
Evolution is Now Degenerating the Human.
BUT
Beneficial Mutations are extremely rare.
http://www.pnas.org/content/98/3/1113.full.pdf
I have to wonder if those studies account for the general populations across the board.
Now if I'm not mistaken:
Maybe you'd like to discuss how selecting a species with large N and very small Ne for a probability calculation involving the expression Ne/N, and then passing off the resulting low probability as typical, is good honest science.
Is covered by the above, otherwise let me know if I'm incorrect in applying those links to this.
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