Ivermectin, ‘Wonder drug’ from Japan: the human use perspective

[We Never Know]

Ivermectin has been used on billions of humans for 40-50 years. Studies show its safe for humans. They know its safe.

So how did it all if a sudden become unsafe because of covid?

This link its from ncbi.nlm.nih.gov...not a junk or conspiracy site

"Discovered in the late-1970s, the pioneering drug ivermectin, a dihydro derivative of avermectin—originating solely from a single microorganism isolated at the Kitasato Intitute, Tokyo, Japan from Japanese soil—has had an immeasurably beneficial impact in improving the lives and welfare of billions of people throughout the world. Originally introduced as a veterinary drug, it kills a wide range of internal and external parasites in commercial livestock and companion animals. It was quickly discovered to be ideal in combating two of the world’s most devastating and disfiguring diseases which have plagued the world’s poor throughout the tropics for centuries. It is now being used free-of-charge as the sole tool in campaigns to eliminate both diseases globally. It has also been used to successfully overcome several other human diseases and new uses for it are continually being found. This paper looks in depth at the events surrounding ivermectin’s passage from being a huge success in Animal Health into its widespread use in humans, a development which has led many to describe it as a “wonder” drug."



"Ivermectin has continually proved to be astonishingly safe for human use. Indeed, it is such a safe drug, with minimal side effects, that it can be administered by non-medical staff and even illiterate individuals in remote rural communities, provided that they have had some very basic, appropriate training. This fact has helped contribute to the unsurpassed beneficial impact that the drug has had on human health and welfare around the globe, especially with regard to the campaign to fight Onchocerciasis."


Ivermectin, ‘Wonder drug’ from Japan: the human use perspective

 

[VoidCat]

Ivermectin has been used on billions of humans for 40-50 years. Studies show its safe for humans. They know its safe.

So how did it all if a sudden become unsafe because of covid?

This link its from ncbi.nlm.nih.gov...not a junk or conspiracy site

"Discovered in the late-1970s, the pioneering drug ivermectin, a dihydro derivative of avermectin—originating solely from a single microorganism isolated at the Kitasato Intitute, Tokyo, Japan from Japanese soil—has had an immeasurably beneficial impact in improving the lives and welfare of billions of people throughout the world. Originally introduced as a veterinary drug, it kills a wide range of internal and external parasites in commercial livestock and companion animals. It was quickly discovered to be ideal in combating two of the world’s most devastating and disfiguring diseases which have plagued the world’s poor throughout the tropics for centuries. It is now being used free-of-charge as the sole tool in campaigns to eliminate both diseases globally. It has also been used to successfully overcome several other human diseases and new uses for it are continually being found. This paper looks in depth at the events surrounding ivermectin’s passage from being a huge success in Animal Health into its widespread use in humans, a development which has led many to describe it as a “wonder” drug."



"Ivermectin has continually proved to be astonishingly safe for human use. Indeed, it is such a safe drug, with minimal side effects, that it can be administered by non-medical staff and even illiterate individuals in remote rural communities, provided that they have had some very basic, appropriate training. This fact has helped contribute to the unsurpassed beneficial impact that the drug has had on human health and welfare around the globe, especially with regard to the campaign to fight Onchocerciasis."


Ivermectin, ‘Wonder drug’ from Japan: the human use perspective

It's the fact to my knowledge that folks are getting it from an animal supply stores as in doses meant for horses not humans. If they had a prescription for human use and the dosage was correct might not be such problems

 

[VoidCat]

Here a quote from the fda's statement on it Why You Should Not Use Ivermectin to Treat or Prevent COVID-19

• FDA has not approved ivermectin for use in treating or preventing COVID-19 in humans. Ivermectin tablets are approved at very specific doses for some parasitic worms, and there are topical (on the skin) formulations for head lice and skin conditions like rosacea. Ivermectin is not an anti-viral (a drug for treating viruses).
• Taking large doses of this drug is dangerous and can cause serious harm.
• If you have a prescription for ivermectin for an FDA-approved use, get it from a legitimate source and take it exactly as prescribed.
• Never use medications intended for animals on yourself. Ivermectin preparations for animals are very different from those approved for humans.

 

[We Never Know]

It's the fact to my knowledge that folks are getting it from an animal supply stores as in doses meant for horses not humans. If they had a prescription for human use and the dosage was correct might not be such problems

Its the same drug. You just have to know the dosage which can easily be explained by a Dr or found on the internet.

 

[VoidCat]

Its the same drug. You just have to know the dosage which can easily be explained by a Dr or found on the internet.

It's prepared differently when it comes to animals according to the fda

 

[We Never Know]

Here a quote from the fda's statement on it Why You Should Not Use Ivermectin to Treat or Prevent COVID-19

• FDA has not approved ivermectin for use in treating or preventing COVID-19 in humans. Ivermectin tablets are approved at very specific doses for some parasitic worms, and there are topical (on the skin) formulations for head lice and skin conditions like rosacea. Ivermectin is not an anti-viral (a drug for treating viruses).
• Taking large doses of this drug is dangerous and can cause serious harm.
• If you have a prescription for ivermectin for an FDA-approved use, get it from a legitimate source and take it exactly as prescribed.
• Never use medications intended for animals on yourself. Ivermectin preparations for animals are very different from those approved for humans.

Read the study I posted. Its legit. And it has been used on billions of humans for 40-50 years.

 

[VoidCat]

It's prepared differently when it comes to animals according to the fda

From link I posted above:

For one thing, animal drugs are often highly concentrated because they are used for large animals like horses and cows, which can weigh a lot more than we do—a ton or more. Such high doses can be highly toxic in humans.

Moreover, FDA reviews drugs not just for safety and effectiveness of the active ingredients, but also for the inactive ingredients. Many inactive ingredients found in animal products aren’t evaluated for use in people. Or they are included in much greater quantity than those used in people. In some cases, we don’t know how those inactive ingredients will affect how ivermectin is absorbed in the human body.

 

[We Never Know]

It's prepared differently when it comes to animals according to the fda

People say the same about penicillian and amoxicillian you can get at pet stores.
When i was younger and got sick, I went to the pet stores. Its cheaper. You can still get 100 250mg pills for $21.50 plus no Dr bill.

 

[dybmh]

So how did it all if a sudden become unsafe because of covid?

Have you seen this?

"Under section 564 of the Federal Food, Drug, and Cosmetic Act (FD&C Act), when the Secretary of HHS declares that an emergency use authorization is appropriate, FDA may authorize unapproved medical products or unapproved uses of approved medical products to be used in an emergency to diagnose, treat, or prevent serious or life-threatening diseases or conditions caused by CBRN threat agents when certain criteria are met, including there are no adequate, approved, and available alternatives. The HHS declaration to support such use must be based on one of four types of determinations of threats or potential threats by the Secretary of HHS, Homeland Security, or Defense."

Source: FDA.gov Emergency Use Authorization

 

[VoidCat]

People say the same about penicillian and amoxicillian you can get at pet stores.
When i was younger and got sick, I went to the pet stores. Its cheaper. You can still get 100 250mg pills for $21.50 plus no Dr bill.

Look I only just heard about this today this morning. I don't know enough to make any more comments then I already did. I don't have a strong opinion but I don't think it's a good idea to take meds that the fda advises against using in a certain way

 

[We Never Know]

From link I posted above:

For one thing, animal drugs are often highly concentrated because they are used for large animals like horses and cows, which can weigh a lot more than we do—a ton or more. Such high doses can be highly toxic in humans.

Moreover, FDA reviews drugs not just for safety and effectiveness of the active ingredients, but also for the inactive ingredients. Many inactive ingredients found in animal products aren’t evaluated for use in people. Or they are included in much greater quantity than those used in people. In some cases, we don’t know how those inactive ingredients will affect how ivermectin is absorbed in the human body.

Like I said the dosages are different.

 

[Debater Slayer]

Read the study I posted. Its legit. And it has been used on billions of humans for 40-50 years.

Taking any drug for something it can't treat can be dangerous, since you're risking getting side effects for no benefit whatsoever. It is similar with, say, antipsychotics, which are essential for treating schizophrenia even with their relatively heavy side-effect profile but can be extremely damaging if used without benefits that outweigh the risks.

Couple that with something like antibiotic resistance from overuse of certain drugs and you can see why many medications should be prescribed judiciously and under professional supervision for their intended effects rather than for diseases for which they're unproved and ineffective as treatments.

Most medications in circulation today are generally safe when taken as prescribed by a doctor and for their intended uses. That doesn't mean we should try to use any of them for other diseases that they can't treat and consequently risk getting side effects or developing resistance to them for no benefit in return.

 

[We Never Know]

Look I only just heard about this today this morning. I don't know enough to make any more comments then I already did. I don't have a strong opinion but I don't think it's a good idea to take meds that the fda advises against using in a certain way

Don't you trust a governemt study with over 60 references? That's what I linked.

 

[VoidCat]

Like I said the dosages are different.

Don't you trust a governemt study with over 60 references? That's what I linked.

Ivermectin is not for treating viruses. Covid is a virus. It's not safe to use a drug to treat a virus when it doesn't treat viruses

 

[We Never Know]

Taking any drug for something it can't treat can be dangerous, since you're risking getting side effects for no benefit whatsoever. It is similar with, say, antipsychotics, which are essential for treating schizophrenia even with their relatively heavy side-effect profile but can be extremely damaging if used without benefits that outweigh the risks.

Couple that with something like antibiotic resistance from overuse of certain drugs and you can see why many medications should be prescribed judiciously and under professional supervision for their intended effects rather than for diseases for which they're unproved and ineffective as treatments.

Most medications in circulation today are generally safe when taken as prescribed by a doctor and for their intended uses. That doesn't mean we should try to use any of them for other diseases that they can't treat and consequently risk getting side effects or developing resistance to them for no benefit in return.

Since covid its been pushed that ivermectin isn't safe. The study shows its is safe and has been used on humans for over 40-50 years.

 

[We Never Know]

Ivermectin is not for treating viruses. Covid is a virus. It's not safe to use a drug to treat a virus when it doesn't treat viruses

Why don't you read the study.

You would see....

It has also been used to successfully overcome several other human diseases and new uses for it are continually being found.

 

[VoidCat]

Why don't you read the study.

You would see....

It has also been used to successfully overcome several other human diseases and new uses for it are continually being found.

I read it. All the diseases it mentions so far that I've googled are not viral. And the fda says it doesn't treat viruses

 

[VoidCat]

Show me a reputable study where it says it treats viruses and then show me one where it treats covid. From my understanding the fda is
opposed to it cuz it does not to their knowledge treat covid and folks are taking it for that which is unsafe. Not that the drug itself is unsafe just how it's being used

Again I don't know enough so maybe you might find something I havent

 

[Debater Slayer]

Since covid its been pushed that ivermectin isn't safe. The study shows its is safe and has been used on humans for over 40-50 years.

The current WHO and FDA position is that it's ineffective for treatment of COVID, and the large dosages also amplify the unsafety of taking it for such an unintended use. It has been used on humans for over 40-50 years, but not for COVID or other diseases that it is incapable of treating. That's the point.

Haldol has been used for over 50 years mainly to treat psychosis and schizophrenia, and it was a groundbreaking drug at the time of its discovery. However, you can look up for yourself just how dangerous it can be if used inappropriately--whether due to incorrect dosage or due to off-label usage for illnesses it can't treat. This merely underlines the importance of referring to experts and medical evidence before taking any medication. Nobody should take Haldol to treat COVID, for the exact same reason they shouldn't take ivermectin for that: neither is evidenced to be an effective treatment for COVID even though they have both been immensely useful and important for decades in treating the diseases they're intended for.

Many people, me included, would love it if we had a medication for COVID instead of having to get vaccinated and/or mask, socially distance, etc., to avoid the virus. However, in the absence of such a medication, we can't just rush into taking an unproved one for COVID and risking the harmful results of doing so on top of the existing risks from the pandemic.

 

[We Never Know]

The current WHO and FDA position is that it's ineffective for treatment of COVID, and the large dosages also amplify the unsafety of taking it for such an unintended use. It has been used on humans for over 40-50 years, but not for COVID or other diseases that it is incapable of treating. That's the point.

Haldol has been used for over 50 years mainly to treat psychosis and schizophrenia, and it was a groundbreaking drug at the time of its discovery. However, you can look up for yourself just how dangerous it can be if used inappropriately--whether due to incorrect dosage or due to off-label usage for illnesses it can't treat. This merely underlines the importance of referring to experts and medical evidence before taking any medication. Nobody should take Haldol to treat COVID for the same reason they shouldn't take ivermectin for that: neither is evidenced to be an effective treatment for COVID even though they have both been immensely useful and important for decades in treating the diseases they're intended for.

Many people, me included, would love it if we had a medication for COVID instead of having to get vaccinated and/or mask, socially distance, etc., to avoid the virus. However, in the absence of such a medication, we can't just rush into taking an unproved one for COVID and risking the harmful results of doing so on top of the existing risks from the pandemic.

Same source as the OP


In Latin America ivermectin was used with satisfactory outcomes. Comparing 704 hospitalized patients who received a dose of ivermectin (150 μg/kg) with 704 controls, it was found lower mortality rates among mechanically ventilated patients who had received the medication (7.3% vs. 1.3%). Overall mortality was lower in cases (1.4%) than in controls (8.5%) with a hazard ratio (HR) of 0.2, 95% CI: 0.11–0.37 (p < 0.0001).3 This single-dose scheme has been conventionally used in various parasitical diseases; however, given that ivermectin is known to be safe and well tolerated, and a single dose may not be sufficient for viral diseases such as Covid-19, further studies are warranted.

Ivermectin has a demonstrated anti-inflammatory effect in vivo and in vitro, that works by reducing the production of TNF-alpha, IL-1 and IL-6, and suppressing LPS-induced NF-kB translocation.4 In mice, the administration of 2 mg/kg of ivermectin suppresses mucus hypersecretion in the respiratory tract and decreases the recruitment of immune cells and the production of cytokines and IgE/IgG1 in bronchoalveolar lavage.5 This shows that ivermectin has an anti-inflammatory effect not only at a systemic level, but also on the lung tissue.

Antiviral and anti-inflammatory properties of ivermectin and its potential use in Covid-19