Ivermectin, ‘Wonder drug’ from Japan: the human use perspective

[VoidCat]

given that ivermectin is known to be safe and well tolerated, and a single dose may not be sufficient for viral diseases such as Covid-19, further studies are warranted.

meaning they don't know yet if it can treat it...further studies are needed

 

[lewisnotmiller]

Don't you trust a governemt study with over 60 references? That's what I linked.

That says it's safe when used as directed?
Sure.

What is your point though?

 

[We Never Know]

That says it's safe when used as directed?
Sure.

What is your point though?

My point is its has been successfully used.
However I'm not saying anyone should run out and start taking it.

Same source as the OP


In Latin America ivermectin was used with satisfactory outcomes. Comparing 704 hospitalized patients who received a dose of ivermectin (150 μg/kg) with 704 controls, it was found lower mortality rates among mechanically ventilated patients who had received the medication (7.3% vs. 1.3%). Overall mortality was lower in cases (1.4%) than in controls (8.5%) with a hazard ratio (HR) of 0.2, 95% CI: 0.11–0.37 (p < 0.0001).3 This single-dose scheme has been conventionally used in various parasitical diseases; however, given that ivermectin is known to be safe and well tolerated, and a single dose may not be sufficient for viral diseases such as Covid-19, further studies are warranted.

Ivermectin has a demonstrated anti-inflammatory effect in vivo and in vitro, that works by reducing the production of TNF-alpha, IL-1 and IL-6, and suppressing LPS-induced NF-kB translocation.4 In mice, the administration of 2 mg/kg of ivermectin suppresses mucus hypersecretion in the respiratory tract and decreases the recruitment of immune cells and the production of cytokines and IgE/IgG1 in bronchoalveolar lavage.5 This shows that ivermectin has an anti-inflammatory effect not only at a systemic level, but also on the lung tissue.

Antiviral and anti-inflammatory properties of ivermectin and its potential use in Covid-19

 

[Debater Slayer]

Same source as the OP


In Latin America ivermectin was used with satisfactory outcomes. Comparing 704 hospitalized patients who received a dose of ivermectin (150 μg/kg) with 704 controls, it was found lower mortality rates among mechanically ventilated patients who had received the medication (7.3% vs. 1.3%). Overall mortality was lower in cases (1.4%) than in controls (8.5%) with a hazard ratio (HR) of 0.2, 95% CI: 0.11–0.37 (p < 0.0001).3 This single-dose scheme has been conventionally used in various parasitical diseases; however, given that ivermectin is known to be safe and well tolerated, and a single dose may not be sufficient for viral diseases such as Covid-19, further studies are warranted.

Ivermectin has a demonstrated anti-inflammatory effect in vivo and in vitro, that works by reducing the production of TNF-alpha, IL-1 and IL-6, and suppressing LPS-induced NF-kB translocation.4 In mice, the administration of 2 mg/kg of ivermectin suppresses mucus hypersecretion in the respiratory tract and decreases the recruitment of immune cells and the production of cytokines and IgE/IgG1 in bronchoalveolar lavage.5 This shows that ivermectin has an anti-inflammatory effect not only at a systemic level, but also on the lung tissue.

Antiviral and anti-inflammatory properties of ivermectin and its potential use in Covid-19

Latin America has multiple corrupt regimes such as that of Brazil who, instead of improving their pandemic response, have been trying to use unproved treatments both as a cheaper and more available "response." You can read more about the problems with this here:

Latin America’s embrace of unproven COVID treatment hinders drug trials

I found these two excerpts particularly noteworthy:

Peru and Bolivia have been transparent about how slim the evidence is for using ivermectin against COVID-19. “It is a product that does not have scientific validation in the treatment of the coronavirus,” acknowledged Bolivian health minister Marcelo Navajas in a press conference on 12 May.

Although most people tolerate ivermectin well, it has been linked to tremors, convulsions, lethargy and disorientation. A 2018 analysis found cases of brain damage and coma in people with a genetic mutation that allows ivermectin to pass from the bloodstream into the brain3.

“What we’re having is a populist treatment, instead of an evidence-based treatment,” says García.

 

[VoidCat]

I read it. All the diseases it mentions so far that I've googled are not viral. And the fda says it doesn't treat viruses

Ok I had skimmed it. Rereading to comprehend better I take back what I said. I don't know enough. It might treat covid it might not. Still I wouldn't use it without a doctor permission

 

[VoidCat]

Latin America has multiple corrupt regimes such as that of Brazil who, instead of improving their pandemic response, have been trying to use unproved treatments both as a cheaper and more available "response." You can read more about the problems with this here:

Latin America’s embrace of unproven COVID treatment hinders drug trials

I found these two excerpts particularly noteworthy:

Ok this is good for me to note

 

[We Never Know]

Latin America has multiple corrupt regimes such as that of Brazil who, instead of improving their pandemic response, have been trying to use unproved treatments both as a cheaper and more available "response." You can read more about the problems with this here:

Latin America’s embrace of unproven COVID treatment hinders drug trials

I found these two excerpts particularly noteworthy:

And people can say....

Although most people tolerate the vaccine well, it has been linked to Guillain-Barré syndrome, thrombosis, anaphylaxis, myocarditis, pericarditis and even death. Long term side effects unknown.

My point is all drugs have side effects.

COVID-19 Vaccination

 

[We Never Know]

Latin America has multiple corrupt regimes such as that of Brazil who, instead of improving their pandemic response, have been trying to use unproved treatments both as a cheaper and more available "response." You can read more about the problems with this here:

Latin America’s embrace of unproven COVID treatment hinders drug trials

I found these two excerpts particularly noteworthy:

And yes, I expect to get a lot of crap for this. But hey I do like to research and read fir myself. I've never been the "just do as your told type".

 

[Debater Slayer]

And people can say....

Although most people tolerate the vaccine well, it has been linked to Guillain-Barré syndrome, thrombosis, anaphylaxis, myocarditis, pericarditis and even death.

My point is all drugs have side effects.

COVID-19 Vaccination

Yes, all drugs and vaccines have potential side effects--obviously to varying extents of rarity or probability--which is why weighing the potential risks and benefits with a doctor is important.

As far as I can see, the odds of getting any serious side effects from a vaccine are so small as to be nowhere near outweighing the benefits in most cases. The tiny minority of people whose risks from vaccines outweigh the benefits should discuss that with their doctors, but for most people, the vaccines are quite safe.

It also seems to me that the risks of taking ivermectin for COVID far outweigh the benefits, since the latter aren't evidenced to even exist for COVID treatment.

 

[Debater Slayer]

And yes, I expect to get a lot of crap for this. But hey I do like to research and read fir myself. I've never been the "just do as your told type".

Reading is good and important, provded that one doesn't let unreliable sources or misinformation deter them from following medical consensus and discussing their individual situation with their doctors. In my opinion, the knowledge of how to think is more important than a mere direction about what to think: I believe the latter is often a function of the former.

 

[We Never Know]

Reading is good and important, provded that one doesn't let unreliable sources or misinformation deter them from following medical consensus and discussing their individual situation with their doctors. In my opinion, the knowledge of how to think is more important than a mere direction about what to think: I believe the latter is often a function of the former.

I don't believe "ncbi.nlm.nih.gov" is a
unreliable source.

 

[Debater Slayer]

I don't believe "ncbi.nlm.nih.gov" is a
unreliable source.

It isn't, but the studies on it are of varying soundness. Not all of them align with peer-reviewed medical consensus, and many are outdated by now. That's another reason reading from different (but still reliable) sources is useful.

 

[We Never Know]

Yes, all drugs and vaccines have potential side effects--obviously to varying extents of rarity or probability--which is why weighing the potential risks and benefits with a doctor is important.

As far as I can see, the odds of getting any serious side effects from a vaccine are so small as to be nowhere near outweighing the benefits in most cases. The tiny minority of people whose risks from vaccines outweigh the benefits should discuss that with their doctors, but for most people, the vaccines are quite safe.

It also seems to me that the risks of taking ivermectin for COVID far outweigh the benefits, since the latter aren't evidenced to even exist for COVID treatment.

I myself haven't taken it. I've had covid. But I do know several that have taken/do take it.
Even a few in the medical field(wifes friends). None of them have gotten covid or had any side effects, and I will add... so far.

 

[Revoltingest]

If people eschew vaccines for Ivermectin because they're
scared of the former's side effects, they should look into
Ivermectin's too (IMO). Also, if FDA approval was reason
to avoid Covid 19 vaccines, note that Ivermectin isn't
approved for it....especially the farm animal versions (IMO).
Florida Poison Control Reports Sudden Uptick in Ivermectin Calls
State's poison control calls climb after ivermectin falsely touted as Covid treatment - CNN Video
Why You Should Not Use Ivermectin to Treat or Prevent COVID-19
How it works....
Parasites: Learning a Worm-Killer’s Modus Operandi (Published 2010)
More info....
Ivermectin - Wikipedia

And for those concerned about nanobots & micro-chips, why
believe those aren't in Ivermectin too?

Finally, Merck (its developer & maker) recommends against
using it for Covid 19 (see link). Big Pharma knocks it's own money maker?
Merck Statement on Ivermectin use During the COVID-19 Pandemic - Merck.com
Excerpted....
KENILWORTH, N.J., Feb. 4, 2021 – Merck (NYSE: MRK), known as MSD outside the United States and Canada, today affirmed its position regarding use of ivermectin during the COVID-19 pandemic. Company scientists continue to carefully examine the findings of all available and emerging studies of ivermectin for the treatment of COVID-19 for evidence of efficacy and safety. It is important to note that, to-date, our analysis has identified:

• No scientific basis for a potential therapeutic effect against COVID-19 from pre-clinical studies;
• No meaningful evidence for clinical activity or clinical efficacy in patients with COVID-19 disease, and;
• A concerning lack of safety data in the majority of studies.

We do not believe that the data available support the safety and efficacy of ivermectin beyond the doses and populations indicated in the regulatory agency-approved prescribing information.

 

[We Never Know]

If people eschew vaccines for Ivermectin because they're
scared of the former's side effects, they should look into
Ivermectin's too (IMO). Also, if FDA approval was reason
to avoid Covid 19 vaccines, note that Ivermectin isn't
approved for it....especially the farm animal versions (IMO).
Florida Poison Control Reports Sudden Uptick in Ivermectin Calls
State's poison control calls climb after ivermectin falsely touted as Covid treatment - CNN Video
Why You Should Not Use Ivermectin to Treat or Prevent COVID-19
How it works....
Parasites: Learning a Worm-Killer’s Modus Operandi (Published 2010)

Yep I've read all that too. Like everything there are good and bad. You never see me only talk about the good or the bad in anything. I talk about both. Be it politics, meds, or what ever.
I try to point out both good(if any) and bad(if any)

 

[Revoltingest]

Yep I've read all that too. Like everything there are good and bad. You never see me only talk about the good or the bad in anything. I talk about both. Be it politics, meds, or what ever.
I try to point out both good(if any) and bad(if any)

Tis good to not discourage Covid 19 vaccination.

 

[lewisnotmiller]

My point is its has been successfully used.
However I'm not saying anyone should run out and start taking it.

Same source as the OP


In Latin America ivermectin was used with satisfactory outcomes. Comparing 704 hospitalized patients who received a dose of ivermectin (150 μg/kg) with 704 controls, it was found lower mortality rates among mechanically ventilated patients who had received the medication (7.3% vs. 1.3%). Overall mortality was lower in cases (1.4%) than in controls (8.5%) with a hazard ratio (HR) of 0.2, 95% CI: 0.11–0.37 (p < 0.0001).3 This single-dose scheme has been conventionally used in various parasitical diseases; however, given that ivermectin is known to be safe and well tolerated, and a single dose may not be sufficient for viral diseases such as Covid-19, further studies are warranted.

Ivermectin has a demonstrated anti-inflammatory effect in vivo and in vitro, that works by reducing the production of TNF-alpha, IL-1 and IL-6, and suppressing LPS-induced NF-kB translocation.4 In mice, the administration of 2 mg/kg of ivermectin suppresses mucus hypersecretion in the respiratory tract and decreases the recruitment of immune cells and the production of cytokines and IgE/IgG1 in bronchoalveolar lavage.5 This shows that ivermectin has an anti-inflammatory effect not only at a systemic level, but also on the lung tissue.

Antiviral and anti-inflammatory properties of ivermectin and its potential use in Covid-19

Okay. Still not really sure what your point is. Lots of things have been 'successfully used'.
In any case, I might bow out at this point.

Cheers.

 

[Revoltingest]

Okay. Still not really sure what your point is. Lots of things have been 'successfully used'.
In any case, I might bow out at this point.

How successful can it be if its manufacturer opposes
its use for Covid 19? They stand to make money
on sales, yet they won't approve this usage?
IMO this should be a big red flag.

 

[lewisnotmiller]

How successful can it be if its manufacturer opposes
its use for Covid 19? They stand to make money
on sales, yet they won't approve this usage?
IMO this should be a big red flag.

Yep, agreed. The OP seems to be arguing that the drug has been safely used with humans. That's all well and good, but appears to have very little to do with it's application in a COVID-context.
I don't have any skin in this game, just confused what point the OP is trying to drive to.

 

[9-10ths_Penguin]

Its the same drug. You just have to know the dosage which can easily be explained by a Dr or found on the internet.

I won't take that COVID vaccine! It's too untested! 2 billion people vaccinated isn't enough data!

Now... can you get me some of that horse deworming medicine? I'll go with that instead.