Ivermectin, ‘Wonder drug’ from Japan: the human use perspective

[We Never Know]

Okay. Still not really sure what your point is. Lots of things have been 'successfully used'.
In any case, I might bow out at this point.

Cheers.

I bow out as well. If anyone wants to read the links they can, or not.
What gets me if someone posts something that doesn't go with what someone thinks, then that poster must be presenting false news, promoting don't take the vax, etc.
The web is full of legit information. Its sad people don't research it on many things.

 

[Revoltingest]

I bow out as well. If anyone wants to read the links they can, or not.
What gets me if someone posts something that doesn't go with what someone thinks, then that poster must be presenting false news, promoting don't take the vax, etc.
The web is full of legit information. Its sad people don't research it on many things.

I posted quite a bit of info about Ivermectin.
Pro-Ivermectin types haven't responded to it.

 

[lewisnotmiller]

I bow out as well. If anyone wants to read the links they can, or not.
What gets me if someone posts something that doesn't go with what someone thinks, then that poster must be presenting false news, promoting don't take the vax, etc.
The web is full of legit information. Its sad people don't research it on many things.

Speaking only for myself, I didn't say any of that. Just not really able to work out what your point for the OP was. In any case...take care.

 

[Deeje]

I posted quite a bit of info about Ivermectin.
Pro-Ivermectin types haven't responded to it.

I'd like to see that can you post a link?

Has anyone heard of monoclonal antibodies? Apparently this treatment was the reason why the former President of the US recovered so well.

"Older adults, people with a high BMI and individuals with certain medical conditions are eligible for a treatment experts say can dramatically reduce risk of severe COVID-19 disease."

Monoclonal antibody treatment for COVID-19: How they work and who is eligible

I am still trying to understand "eligibility" for a treatment that has been around for ages, and has worked in trials to keep 70% of people out of hospital....how is not getting sick and dying from C19 not an eligibility?
This treatment works as a preventative, so why are frontline health workers not given it as a matter of course?

None of this C19 stuff makes any logical sense. It is all based on fear, not reality. Why withhold treatments that have been proven to be effective, both as an early intervention and as a preventative? *SMH*

 

[oldbadger]

Ivermectin has been used on billions of humans for 40-50 years. Studies show its safe for humans. They know its safe.

Have you been taking it?
Could you share your experiences of it with us, please?

 

[Dan From Smithville]

It is unclear what the intent of the OP is, but this may help clarify things a bit. The study referenced in the OP is not a study and not sponsored by the US government. It is a review paper as indicated in the abstract and sponsored by the Japan Academy, Japan's national science academy. "This paper looks in depth at the events surrounding ivermectin’s passage from being a huge success in Animal Health into its widespread use in humans, a development which has led many to describe it as a “wonder” drug." It focuses on the discovery, history, and veterinary and human medical use in controlling endoparasitic helminths and ectoparasitic arthropods. The review doesn't discuss any potential use of ivermectin as an antiviral medication. The current state of knowledge on this is that there is mixed evidence on viral efficacy and no established clinical evidence supporting the use of ivermectin in controlling Covid-19 or combating SARS-CoV-2

Additionally, reputable medical organizations (including the FDA and Merck) do not recommend self medicating with veterinary grade pharmaceuticals due to differences in dosage, formulation and other factors that contraindicate such usage. That said, this is a very good review of a very useful chemical that may have further potential benefits in wider areas of agriculture and human health. There has been some renewed interest in the last 20 or so years in the discovery of alternate uses for existing chemistry. Even a compound with a dubious history like that of thalidomide has been found to have uses as a treatment for some cancers and in skin conditions related to Hansen's disease. The value found in exploring our existing chemistry set is that we already know a great deal about these chemicals, their target and nontarget effects, rendering them more cost effective for screening and further development.

What I find ironic is that there are many people that are antagonistic to and untrusting of the claims from evidence-based research of large pharmaceutical and chemical companies and governments, but will promote the unqualified claims by random persons or groups just because they are on the internet and those claims fit their personal and biased agendas. They don't trust the promotion of vaccines, but if John Doe posts his miracle cure on the internet, they are swift to glom onto it. However, while the intent of the OP is somewhat opaque, it does not seem to fit that mold and appears to be purely informational.

 

[oldbadger]

Thread Title:-
Ivermectin, ‘Wonder drug’ from Japan: the human use perspective

Has any member been taking Ivermectin?
If so...... can you tell us about that, please?

Me? I've had two AZ vaccinations.
Months later I feel ok. I've been in to hospital several times since then, had minor and major surgeries, lost a bunch of intestine, and a kidney, and robots couldn't clear out the mess, so 'open surgery'...... been rushed back to hospital with bouncy heartbeat (fibrillations) and ileus, spent many many days in hospitals which are THE places to catch Covid, you know....... and.... no probs with Covid.

You have you all been?

 

[Dan From Smithville]

Thread Title:-
Ivermectin, ‘Wonder drug’ from Japan: the human use perspective

Has any member been taking Ivermectin?
If so...... can you tell us about that, please?

Me? I've had two AZ vaccinations.
Months later I feel ok. I've been in to hospital several times since then, had minor and major surgeries, lost a bunch of intestine, and a kidney, and robots couldn't clear out the mess, so 'open surgery'...... been rushed back to hospital with bouncy heartbeat (fibrillations) and ileus, spent many many days in hospitals which are THE places to catch Covid, you know....... and.... no probs with Covid.

You have you all been?

AZ? AstraZeneca?

I had both of the Pfizer BioNTech vaccines with no initial issues (other than normal injection site pain that lasted less than 8 hours) and no additional issues since.

 

[Revoltingest]

I'd like to see that can you post a link?

My post #34 has several useful ones.
But the most compelling reason (IMO) to be skeptical of Ivermectin
being useful against Covid 19 is that its maker, Merck, doesn't
authorize the drug for that application. Why would they turn
down all that loot from sales?

 

[We Never Know]

It is unclear what the intent of the OP is, but this may help clarify things a bit. The study referenced in the OP is not a study and not sponsored by the US government. It is a review paper as indicated in the abstract and sponsored by the Japan Academy, Japan's national science academy. "This paper looks in depth at the events surrounding ivermectin’s passage from being a huge success in Animal Health into its widespread use in humans, a development which has led many to describe it as a “wonder” drug." It focuses on the discovery, history, and veterinary and human medical use in controlling endoparasitic helminths and ectoparasitic arthropods. The review doesn't discuss any potential use of ivermectin as an antiviral medication. The current state of knowledge on this is that there is mixed evidence on viral efficacy and no established clinical evidence supporting the use of ivermectin in controlling Covid-19 or combating SARS-CoV-2

Additionally, reputable medical organizations (including the FDA and Merck) do not recommend self medicating with veterinary grade pharmaceuticals due to differences in dosage, formulation and other factors that contraindicate such usage. That said, this is a very good review of a very useful chemical that may have further potential benefits in wider areas of agriculture and human health. There has been some renewed interest in the last 20 or so years in the discovery of alternate uses for existing chemistry. Even a compound with a dubious history like that of thalidomide has been found to have uses as a treatment for some cancers and in skin conditions related to Hansen's disease. The value found in exploring our existing chemistry set is that we already know a great deal about these chemicals, their target and nontarget effects, rendering them more cost effective for screening and further development.

What I find ironic is that there are many people that are antagonistic to and untrusting of the claims from evidence-based research of large pharmaceutical and chemical companies and governments, but will promote the unqualified claims by random persons or groups just because they are on the internet and those claims fit their personal and biased agendas. They don't trust the promotion of vaccines, but if John Doe posts his miracle cure on the internet, they are swift to glom onto it. However, while the intent of the OP is somewhat opaque, it does not seem to fit that mold and appears to be purely informational.

ncbi.nlm.nih.gov == The National Center for Biotechnology Information (NCBI) is part of the United States National Library of Medicine (NLM), a branch of the National Institutes of Health (NIH). It is approved and funded by the government of the United States.

 

[Revoltingest]

What is it with people latching onto miracle
cures, eh. Taking bleach. Taking hydroxychloroquine.
And now taking a horse de-wormer, Ivermectin.
Will the Revigator make its return? (I had one once.)
Ref...
10 Wacky Vintage Cures Con Artists Sold To The Masses - Listverse

 

[We Never Know]

What is it with people latching onto miracle
cures, eh. Taking bleach. Taking hydroxychloroquine.
And now taking a horse de-wormer, Ivermectin.
Will the Revigator make its return? (I had one once.)
Ref...
10 Wacky Vintage Cures Con Artists Sold To The Masses - Listverse

I don't understand how hydroxychloroquine,
which is a immunosuppressive drug, would help. I would think the last thing anyone with covid needs is to have their immune response suppressed. But I'm no expert.



Immunosuppressive drug
An agent that decreases the body's immune responses. It reduces the body's ability to fight infections and other diseases, such as cancer.

 

[Dan From Smithville]

I wanted to mention that NCBI is the source of the Review article, but they did not publish or fund the production of the article linked in the OP. Being well aware and very appreciative to the existence of the NCBI--an archive for assembling and disseminating existing scientific information from any of many publishers--I think that the association as part of the federal government may confuse people into thinking this was some sort of 'study' produced by the government.

Essentially, part of the NCBI is an internet library accessible to the public. Like any library, they hold quantities of materials that they never published or funded. Making them available does not make an endorsement of the material.

 

[Dan From Smithville]

My post #34 has several useful ones.
But the most compelling reason (IMO) to be skeptical of Ivermectin
being useful against Covid 19 is that its maker, Merck, doesn't
authorize the drug for that application. Why would they turn
down all that loot from sales?

If they think there is some sort of efficacy and can find a formulation that works, they might have teams working on it, but the fact that they are not jumping right on this is a good indication they do not have the sort of evidence they want and need to warrant the application.

 

[Secret Chief]

billions

Seems a lot. I've never heard of it.


"In 2018, it was the 420th most commonly prescribed medication in the United States, with more than one hundred thousand prescriptions.

During the COVID-19 pandemic, misinformation was widely spread claiming that ivermectin is beneficial for treating and preventing COVID-19.Such claims are not backed by credible scientific evidence."

- Ivermectin - Wikipedia

 

[Revoltingest]

Ivermectin has been used on billions of humans for 40-50 years. Studies show its safe for humans. They know its safe.

So how did it all if a sudden become unsafe because of covid?

This link its from ncbi.nlm.nih.gov...not a junk or conspiracy site

"Discovered in the late-1970s, the pioneering drug ivermectin, a dihydro derivative of avermectin—originating solely from a single microorganism isolated at the Kitasato Intitute, Tokyo, Japan from Japanese soil—has had an immeasurably beneficial impact in improving the lives and welfare of billions of people throughout the world. Originally introduced as a veterinary drug, it kills a wide range of internal and external parasites in commercial livestock and companion animals. It was quickly discovered to be ideal in combating two of the world’s most devastating and disfiguring diseases which have plagued the world’s poor throughout the tropics for centuries. It is now being used free-of-charge as the sole tool in campaigns to eliminate both diseases globally. It has also been used to successfully overcome several other human diseases and new uses for it are continually being found. This paper looks in depth at the events surrounding ivermectin’s passage from being a huge success in Animal Health into its widespread use in humans, a development which has led many to describe it as a “wonder” drug."



"Ivermectin has continually proved to be astonishingly safe for human use. Indeed, it is such a safe drug, with minimal side effects, that it can be administered by non-medical staff and even illiterate individuals in remote rural communities, provided that they have had some very basic, appropriate training. This fact has helped contribute to the unsurpassed beneficial impact that the drug has had on human health and welfare around the globe, especially with regard to the campaign to fight Onchocerciasis."


Ivermectin, ‘Wonder drug’ from Japan: the human use perspective

What do you think of Merck, Ivermectin's manufacturer,
saying....
KENILWORTH, N.J., Feb. 4, 2021 – Merck (NYSE: MRK), known as MSD outside the United States and Canada, today affirmed its position regarding use of ivermectin during the COVID-19 pandemic. Company scientists continue to carefully examine the findings of all available and emerging studies of ivermectin for the treatment of COVID-19 for evidence of efficacy and safety. It is important to note that, to-date, our analysis has identified:

• No scientific basis for a potential therapeutic effect against COVID-19 from pre-clinical studies;
• No meaningful evidence for clinical activity or clinical efficacy in patients with COVID-19 disease, and;
• A concerning lack of safety data in the majority of studies.

Ref...
Merck Statement on Ivermectin use During the COVID-19 Pandemic - Merck.com
----------------------------------------------------------------------------------------------
To post information that appears positive about using Ivermectin in the
context of curing or mitigating Covid 19 without addressing Merck's
own denial of efficacy strikes me as dangerous because it would
encourage some to continue using horse de-wormer medicine in
lieu of vaccination, mask wearing, social separation, & hygiene....IMO.

What is your intent in this presentation of partial information?

Disclaimer:
I am not attacking Ivermectin, which has proven very useful to
treat parasites in humans, horses & cattle. I am pro-Ivermectin
for intended uses. But it is factual to say it's not a miracle cure-all.
Please people....do not buy horse de-wormer chemicals from
feed stores for human internal use, lest poison control centers
be overwhelmed.

 

[We Never Know]

What do you think of Merck, Ivermectin's manufacturer,
saying....
KENILWORTH, N.J., Feb. 4, 2021 – Merck (NYSE: MRK), known as MSD outside the United States and Canada, today affirmed its position regarding use of ivermectin during the COVID-19 pandemic. Company scientists continue to carefully examine the findings of all available and emerging studies of ivermectin for the treatment of COVID-19 for evidence of efficacy and safety. It is important to note that, to-date, our analysis has identified:

• No scientific basis for a potential therapeutic effect against COVID-19 from pre-clinical studies;
• No meaningful evidence for clinical activity or clinical efficacy in patients with COVID-19 disease, and;
• A concerning lack of safety data in the majority of studies.

Ref...
Merck Statement on Ivermectin use During the COVID-19 Pandemic - Merck.com
----------------------------------------------------------------------------------------------
To post information that appears positive about using Ivermectin in the
context of curing or mitigating Covid 19 without addressing Merck's
own denial of efficacy strikes me as dangerous because it would
encourage some to continue using horse de-wormer medicine in
lieu of vaccination, mask wearing, social separation, & hygiene....IMO.

What is your intent in this presentation of partial information?

Disclaimer:
I am not attacking Ivermectin, which has proven very useful to
treat parasites in humans, horses & cattle. I am pro-Ivermectin
for intended uses. But it is factual to say it's not a miracle cure-all.
Please people....do not buy horse de-wormer chemicals from
feed stores for human internal use, lest poison control centers
be overwhelmed.

I've read it like I've read the other side of the fence stories. Issuing a statement like that should protect them from lawsuits from people taking it and having adverse effects.

 

[Revoltingest]

I've read it like I've read the other side of the fence stories. Issuing a statement like that should protect them from lawsuits from people taking it and having adverse effects.

I smell a double standard from such posts & threads touting
yet another miracle cure along the lines of....
bleach, hydroxychloriquine, 5G bioshields, betel leaves,
methylene chloride, oleandrin, drinking cow urine, etc, etc.
(Yes, those are all real things I've run across.)

Merck secretly wants to people to buy pig de-worming medicine, & their
advice against it is merely proof of their greed, & Ivermectin's efficacy.
Yet....
Moderna wants people to buy their Covid 19 vaccines. Their making a
profit is proof of their greed & its ineffectiveness.

Why not chop down all 5G towers....it'll create jobs, end
Covid 19 and stop the evil Democrats' radio waves from
activating the micro-chips & nanobots injected into us.

Disclaimer:
The above is just my opinion.

 

[Polymath257]

A relevant article, including how Ivermectin works.

More people are poisoning themselves with horse-deworming drug to thwart COVID

The problem is that people are not taking basic cautions, like making sure they have the correct dose. And they are poisoning themselves as a result.

The (disputed) effects on covid also require doses 100 times as much as are approved for humans, and are toxic to us.

But, there is a run on the livestock supplies to the point that legitimate uses are being constrained.

So, people are poisoning themselves because they don't want to get a safe vaccine and instead opt for a medication with *known* issues at the doses required.

Why do people do this????

 

[We Never Know]

I smell a double standard from such posts & threads touting
yet another miracle cure along the lines of....
bleach, hydroxychloriquine, 5G bioshields, betel leaves,
methylene chloride, oleandrin, drinking cow urine, etc, etc.
(Yes, those are all real things I've run across.)

Merck secretly wants to people to buy pig de-worming medicine, & their
advice against it is merely proof of their greed, & Ivermectin's efficacy.
Yet....
Moderna wants people to buy their Covid 19 vaccines. Their making a
profit is proof of their greed & its ineffectiveness.

Why not chop down all 5G towers....it'll create jobs, end
Covid 19 and stop the evil Democrats' radio waves from
activating the micro-chips & nanobots injected into us.

Disclaimer:
The above is just my opinion.

Lol. If I posted something about ford you would smell that I'm saying chevy and dodge are not good.

Posting about something isn't saying its better or worse.