New research on sensitivity to wheat in the absence of coeliac disease

[Jumi]

Intestinal cell damage and systemic immune activation in individuals reporting sensitivity to wheat in the absence of coeliac disease

I'll just quote the conclusions below, full abstract here: http://gut.bmj.com/content/early/2016/07/21/gutjnl-2016-311964

These findings reveal a state of systemic immune activation in conjunction with a compromised intestinal epithelium affecting a subset of individuals who experience sensitivity to wheat in the absence of coeliac disease.

Here is an article about the research for us common folk:
https://www.sciencedaily.com/releases/2016/07/160726123632.htm

Here's the kicker:

"Our study shows that the symptoms reported by individuals with this condition are not imagined, as some people have suggested," said study co-author Peter H. Green, MD, the Phyllis and Ivan Seidenberg Professor of Medicine at CUMC and director of the Celiac Disease Center. "It demonstrates that there is a biological basis for these symptoms in a significant number of these patients."

 

[DawudTalut]

I'll just quote the conclusions ...........................

Peace be on you.
Thanks for info.
They say the rate is different at various places:
Rates @ http://healthyeating.sfgate.com/asians-gluten-intolerant-6918.html

 

[Burl]

Could be a manifestation of a psychological condition, such as an innate aversion to people of a different mind-set resulting in an association of the phonetic "we" in 'wheat' to irritable bowel syndrome.

 

[Jumi]

Could be a manifestation of a psychological condition, such as an innate aversion to people of a different mind-set resulting in an association of the phonetic "we" in 'wheat' to irritable bowel syndrome.

How do you propose a psychological condition of which there is no proof, damages intestinal cells in a statistically significant way?

 

[Burl]

Yeah, the thesis needs some research. Psychological profiles would help establish some basis, along with specific questions concerning conflict-resolution, and see if a pattern emerges.

 

[Shadow Wolf]

Could be a manifestation of a psychological condition, such as an innate aversion to people of a different mind-set resulting in an association of the phonetic "we" in 'wheat' to irritable bowel syndrome.

I doubt it's psychological. Even in a small part of those with irritable bowel syndrome there are some with an apparent sensitivity to wheat/gluten, and though no tests indicated the presence of Celiac's disease, they report much of the same problems with wheat that those with Celiac's report.

 

[Burl]

I have a biased opinion in that regard, and yet I could be wrong.

 

[Shadow Wolf]

I have a biased opinion in that regard, and yet I could be wrong.

I think there is more to the intestines that what we know. There isn't even a concrete answer as to how IBS happens or what exactly is wrong with someone with it, but there are many ideas ranging from small intestine bacteria balances to neural pathways getting messed up from stress overload. And then there is that small part of those with IBS who do not have Celiac's disease but have the same report over wheat consumption, which seems to overlap with the group mentioned in the OP. It may be that we are stumbling upon discovering that "wheat allergies" encompass a larger range of disorders and syndromes.

 

[Burl]

'Infinite Diversity in Infinite Combinations' can surprise us.

 

[Jumi]

Yeah, the thesis needs some research. Psychological profiles would help establish some basis, along with specific questions concerning conflict-resolution, and see if a pattern emerges.

Well this is the result of research and "It demonstrates that there is a biological basis for these symptoms in a significant number of these patients." After a period of 6 months without wheat/gluten the accumulated cell damage was repaired enough to restore normal functionality.

Sure there are some people who have a no gluten fad or such and frankly that fad's been a mixed bag for myself. It's put more foods without wheat gluten on the shelves, but made them much more expensive.

I have a biased opinion in that regard, and yet I could be wrong.

It's common in food issues. People take their food like religion and politics.