It isn't a negative discrimination to have a blanket injunction against producing genetically defective offspring regardless of sexuality or relation.
You don't have to ban brother and sister from wedding, but if anyone with high possibility of genetic defects has to go through a more rigorous process to have children (such as testing for defects, removing defects with genetic science if possible, etc.) then I don't see any problem aside from subjective revulsion and cultural norms.
You don't have to ban brother and sister from wedding, but if anyone with high possibility of genetic defects has to go through a more rigorous process to have children (such as testing for defects, removing defects with genetic science if possible, etc.) then I don't see any problem aside from subjective revulsion and cultural norms.