If Trump/Vance wins I would feel more comfortable with Vance than Trump, so maybe they could use the 25th amendment by February 2025. Unfortunately for Vance is that he has a huge anchor chained around his neck in the form of Trump.
Trump's supporters tried to kill his last VP for not cooperating in Trump's coup atttempt. I can only imagine the target VP Vance would have on his back if he tried to initiate the process in the 25th Amendment.