What statements exactly do you agree or disagree with relating to "the opioids and weed"?
I assume you don't disagree with the findings of reduced opioid overdose mortality in states with medicinal marijuana laws. I assume that you agree that this one of benefits of legalizing marijuana, along with the other study findings cited in #171.
Antibiotics are one of the drug types that 70% of Americans swallow daily. Here are a couple of the reasons that is detrimental: (1) A recent study published in
JAMA found that of adults seeing the doctor for a sore throat, 70% were prescribed antibiotics, even though only about 10% had Streptococcus, the only common cause of sore throat for which antibiotics are effective:
US Adult Sore Throat Antibiotics, 1997-2010 This is called "injudicious use" of antibiotics, which, as the CDC has urged, is bad because it is the primary factor in the development of drug-resistant bacteria. This is in addition to the fact that (2) even a single course of antibiotic ravages one’s gut microbiome for some 6 months, which causes people to gain weight and contributes to the devastating and horribly expensive obesity problem in the US. Farm animals have long been given daily doses of antibiotics in order to fatten them up; there is every reason to believe that the same effect occurs in humans for the same reasons:
Antibiotics Linked to Weight Gain
Antidepressant drugs are the second most commonly prescribed drugs, which are not just hardly effective compared to placebo, but do more harm than good:
Efficacy and Effectiveness of Antidepressants: Current Status of Research
Meta-analyses of FDA trials suggest that antidepressants are only marginally efficacious compared to placebos and document profound publication bias that inflates their apparent efficacy. These meta-analyses also document a second form of bias in which researchers fail to report the negative results for the prespecified primary outcome measure submitted to the FDA, while highlighting in published studies positive results from a secondary or even a new measure as though it was their primary measure of interest. The STAR * D analysis found that the effectiveness of antidepressant therapies was probably even lower than the modest one reported by the study authors with an apparent progressively increasing dropout rate across each study phase
http://psychrights.org/Research/Dig...essantMetaAnalysisPsychotherPsychosom2010.pdf
Primum non nocere: An evolutionary analysis of whether antidepressants do more harm than good
Most antidepressants are designed to perturb the neurotransmitter serotonin -- an evolutionarily ancient biochemical found in plants, animals and fungi. Many adaptive processes evolved to be regulated by serotonin, including emotion, development, neuronal growth and death, platelet activation and the clotting process, attention, electrolyte balance, and reproduction. It is a principle of evolutionary medicine that the disruption of evolved adaptations will degrade biological functioning. Because serotonin regulates many adaptive processes, antidepressants could have many adverse health effects. For instance . . . they increase the brain’s susceptibility to future episodes after they have been discontinued. Contrary to a widely held belief in psychiatry, studies that purport to show that antidepressants promote neurogenesis are flawed because they all use a method that cannot, by itself, distinguish between neurogenesis and neuronal death. In fact, antidepressants cause neuronal damage and mature neurons to revert to an immature state, both of which may explain why antidepressants also cause neurons to undergo apoptosis (programmed death). Antidepressants can also cause developmental problems, they have adverse effects on sexual and romantic life, and they increase the risk of hyponatremia (low sodium in the blood plasma), bleeding, stroke, and death in the elderly. Our review supports the conclusion that antidepressants generally do more harm than good by disrupting a number of adaptive processes regulated by serotonin.
https://www.researchgate.net/public...hether_antidepressants_do_more_harm_than_good