A rather personal question, but right now I give both time and money to both Philabundance (
www.philabundance.org) a Philadelphia area clearing house for food aid and World Vision (
www.worldvision.org). As well as convincing my church to give $40K to Compassion International (
www.compassioninternational.org)
Also I seriously cut my home energy usage this past year, replacing a clunky old fridge, did not turn on my AC this past summer, just replaced my gas guzzeling car and an getting almost twice the milage that i was.
Its not perfect but its a start.