The philosophy of science does its best to identify and clearly state assumptions, both fundamental ('a world exists external to the self; our senses are capable of informing us of that world; reason is a valid tool') and specific to the particular matter under investigation. Most experiments are expressly to test the correctness of assumptions stated to be such. You'll also be aware of the role of repeatable experiment in scientific method.There can be no science without assumption.
That statement is meaningless until you provide specific examples from history. What are you actually talking about?Somehow nobody noticed that the last century of experiments often don't support the assumptions suggesting a new paradigm is necessary.