Similarly, a study in Australia among people who had mild COVID-19 one year earlier (prior to the prevalence of variants) found that, although most had high levels of IgG antibodies and had circulating T cells and memory B cells against COVID-19, only about half had neutralizing activity against a SARS-CoV-2 virus that was similar to the one that caused the initial infection, and even fewer (16.2%) had neutralizing activity against the Delta variant (Garcia-Valtanen, medRxiv 2021 — preprint). Likewise, a small study among people who experienced mild-to-moderate or severe COVID-19 in early 2020 found that even blood samples that contained high titers of neutralizing antibodies against the original virus had significantly lower neutralizing antibody titers against the Alpha, Beta and Delta variants (Marzi, bioRxiv 2021 — preprint).