Non-Random Directed Mutations were confirmed.
Non-Random Directed Mutations were confirmed. Cells have mechanisms for choosing which mutations will occur. Experiments demonstrated that cells come up repeatedly with just the right ‘adaptive’ or ‘directed’ mutations in specific genes that enable the cells to grow and multiply.
1) In an article dated 2013, James A. Shapiro, a biologist and expert in bacterial genetics said, “Research dating back to the 1930s has shown that genetic change is the result of cell-mediated processes, not simply accidents or damage to the DNA. This cell-active view of genome change applies to all scales of DNA sequence variation, from point mutations to large-scale genome rearrangements and whole genome duplications (WGDs). This conceptual change to active cell inscriptions controlling RW genome functions has profound implications for all areas of the life sciences.”
How life changes itself: the Read-Write (RW) genome - PubMed
https://shapiro.bsd.uchicago.edu/Shapiro.2013.How Life Changes Itself- The Read-Write (RW) Genome.Physics of Life Reviews.pdf
How life changes itself: The Read–Write (RW) genome (uchicago.edu)
2) Nature volume 335, pages142–145, The origin of mutants
“Cells may have mechanisms for choosing which mutations will occur.”
The origin of mutants | Nature
3) Nature volume 485, pages 95–98, Evidence of non-random mutation rates suggests an evolutionary risk management strategy
Evidence of non-random mutation rates suggests an evolutionary risk management strategy | Nature
4) 2012 Suzhou, China, In the international conference of physiological sciences, Denis Noble said “It is difficult (if not impossible) to find a genome change operator that is truly random in its action within the DNA of the cell where it works. All careful studies of mutagenesis find statistically significant non-random patterns of change” , “
not only mutations are not random, but also proteins did not evolve via gradual accumulation of change.”
Non-Random Directed Mutations Confirmed. - YouTube
5) 2013 Birmingham, UK, as the President of the International Union of Physiological Sciences (IUPS), Denis Noble confirmed non-random mutations in his lecture which was published in the journal Experimental Physiology, see the links below
Physiology is rocking the foundations of evolutionary biology - Noble - 2013 - Experimental Physiology - Wiley Online Library
Physiology is rocking the foundations of evolutionary biology (wiley.com)
Physiology moves back onto centre stage: a new synthesis with evolutionary biology - YouTube
6) 2016 “New Trend in Evolutionary Biology” conference in the Royal Society, Gerd B. Müller discussed the challenges of MS theory and the need for the EES. The extended evolutionary synthesis acknowledges developmental bias as one of the core assumptions.
Müller said, “The kind of selectable phenotypic variation that can be produced by a developmental system of a given type is neither infinite nor random. Rather, selectable variation is both constrained and facilitated by development. Before natural selection can act, the developmental system harbours tendencies towards certain solutions, a property that has been called developmental bias”
Here is the article by Gerd B. Müller that was published on 2017.
Why an extended evolutionary synthesis is necessary (royalsocietypublishing.org)
7) January 2022, a recent study of mutations in Arabidopsis was published. Nature wrote, ” Since the first half of the twentieth century, evolutionary theory has been dominated by the idea that mutations occur randomly with respect to their consequences”. “Our discovery yields a new account of the forces driving patterns of natural variation,
challenging a long-standing paradigm regarding the randomness of mutation and inspiring future directions for theoretical and practical research on mutation in biology and evolution.”
Mutation bias reflects natural selection in Arabidopsis thaliana | Nature
January 2022, SciTechDaily wrote,”
DNA Mutations Do Not Occur Randomly – Discovery Transforms Our View of Evolution” , “Mutations of DNA do not occur as randomly as previously assumed, according to new research from Max Planck Institute for Biology Tübingen in Germany and University of California Davis in the US.
The findings have the potential to dramatically change our view of evolution. “
DNA Mutations Do Not Occur Randomly – Discovery Transforms Our View of Evolution (scitechdaily.com)
8) Microorganisms such as bacteria, viruses, fungi and parasites develop the ability to survive against the drugs designed to kill them. Antimicrobial Resistance (AMR) is repeatedly seen and cannot be disputed.
Studies by Harvard University showed that the mutation process happens at a frightening speed, not in years or thousands of generations but within 11 days, bacteria developed defense mechanisms against antibiotics that increased its resistance levels by over 1000-fold. The mutations actually started much earlier with varying levels of resistance till the 1000 fold resistance was achieved in 11 days.
The experiment showed
repeated directed successive mutations that produced a change that didn’t exist in original bacteria. The spread of bacteria stopped at each band until a mutant appeared then the mutants continued to spread to the next band and the mutation process repeated till the accumulating successive mutations adapted to over 1000 fold resistance level against antibiotics.
The fast adaptation response was driven by the threat to the survival of the bacteria. The experiment showed repeated/predictable directed mutation. The process is neither random nor gradual.
See the link and YouTube video below (same video is included in the article).
Scientists reveal the frightening speed at which bacteria can develop antibiotic resistance (smh.com.au)
The Evolution of Bacteria on a “Mega-Plate” Petri Dish (Kishony Lab)`` - YouTube
Lenski’s “Escherichia Coli” experiment itself demonstrates directed mutation. The experiment shows a mediated gene regulation adaptation event that activated an
existing but previously silent citrate transporter through the precise placement beyond an aerobically expressed promoter to allow for the expression of the previously silent citrate transporter. It was not new info but rather an existing inactive info that was activated as an adaptive response to the specific variables within the environment. It’s a clear example of
directed mutation that allows an organism to better adapt to the variables in its niche.
September 2012, Nature wrote about the E Coli experiment,” tandem duplication that captured an aerobically expressed promoter for the expression of a
previously silent citrate transporter.”
Genomic analysis of a key innovation in an experimental Escherichia coli population | Nature
In fact, Research has showed that Bacteria and Viruses are very intelligent, capable of complex decision-making,
they change themselves and adapt to the environment in order to survive. See more about Microbial intelligence in #226
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