I believe on a very small level, yes. That is, if you are mean all the time, people won't like you very much, because you're a jerk. If you are nice to everyone, people will like you and will treat you kindly, so you'll be more likely to get what you want.
On a grand scale, however, I don't believe in karma. That is, if you secretly lie and cheat and steal, you might have a great life, because no one knows that you are doing those things most people dislike, so no one is going to care. So long as you don't get caught, you're going to have a great life, even though you cheated a bunch of people over.