Agreed, science is an effectual study (gather the evidence) of Nature. Now do a keyword search of scientific studies that use both "direct selection and "indirect selection" terms and see how many of the millions of documents use such terms. Then see how such terms were used. You will find that in science, we ignore how we can conduct experiments in the first place which is a fundamental omission error. In science, we ignore the cause of the effects observed in scientific experiments, and since there are two mutually exclusive and jointly exhaustive origin variables that cause all the effects we observe in Nature, the methods used in science are based on omitted-variable bias which in turn leads to false-positive results. This is why "Science is NOT a methodology for establishing truth."