Christian Doc
Member
Response to David M
I think you will also find that natural selection is being skewed by modern technology. For example, in previous generations the weak would have died of infections before breeding these are being treated by modern medicine such that they are able to breed. So if anything, modern medicine is contributing to a weakening of the gene pool. I dont think I would be the only person to recognise that once a species can adapt the environment and improve their survival without the need for mutations they are stepping away from natural selection.
Heredity - Estimation of spontaneous genome-wide mutation rate parameters: whither beneficial mutations?
In the introduction, Most researchers agree that mutations with phenotypic effects are usually deleterious.
The summary statement in the abstract is telling isnt it:
It is argued that, although most if not all mutations detected in mutation accumulation experiments are deleterious, the question of the rate of favourable mutations (and their effects) is still a matter for debate.
[FONT="]In the section that is titled On detecting favourable mutations...[/FONT]
[FONT="][/FONT][FONT="]Yet most experiments looking at multicellular organisms have so far failed to produce any information on such mutations.[/FONT]
[FONT="]I therefore conclude that I am not making wild statements without evidence. I had searched at the time of my university education and this is what I was finding. At the time I had full access to pretty much all the journals online thanks to King College London internet access. I lack that now. However, it is fairly easy to see that the number of beneficial mutations are so small in number as to be improbable to improve the human species.[/FONT]
[FONT="]I think that with Adam and Eve, we started with genetic perfection. Then since that time we have been accumulating mutations ever since then. The variation that we see around the world is due to the mutations of the DNA passed down to us.[/FONT]
[FONT="]So I would argue that we are not evolving up, we are evolving down. I refrain from using the term devolution because somebody would merely point out that evolution does not have a necessary direction. However, I think you can see what I am saying. The human genome is deteriorating at a fast rate. In order for this to be possible, I think that the human species is young.[/FONT]
Just so you can see that this is not an isolated source
High genomic deleterious mutation rates in hominids : Abstract : Nature
I do not have access to the full journal but surely title is suggestive of the content of the article and the background information to it:
[FONT="]High genomic deleterious mutation rates in hominids[/FONT]
Now, dont get me wrong I do not accept their idea that humans are derived from hominids, however, if experts in human genetics are making statements like High genomic deleterious mutation rates in hominids, I can say that mutations in human DNA are almost always deleterious?
I am not without evidence when I say that the vast mutations in humans are deleterious.
Gunfinger,
I suspect that a lot of what you have said has been answered above.
Where are the publications stating the majority of mutations are neutral?
I suspect you will find that where there has been a substantial rise in the standard of living in a culture, the children will be taller than their parents. You will also probably find that they are wider! ;-)
As I said before, humans have got to the stage where we are adapting our environment such that a lot of changes that we see are due to us meddling with our environment or coming up with other strategies such as childhood immunisations, good sanitation etc. As an example of this (which is related to the next bit is lactose intolerance), we may find an increase in congenital lactase deficiency. They previously died as infants, now they may live to reproduce and pass on their autosomal recessive genes. Just one piece of evidence that shows that humans are getting beyond the scope of natural selection we still have selection, it is no longer natural.
Autodidact
However, what we see is that there are people who do not express lactase into adulthood (i.e. not long enough for their culture). They still have the genetic information, they just do not express it. So you are incorrect on this one, hence I couldnt see where you were going with this one. All that is happening is that the lactase is being expressed into adulthood.
The YEC would say that farming was present from Genesis 4 onwards. Thus, I would say that lactase was present and expressed into adulthood at the beginning. People then no longer expressed it into adulthood because of a nomadic life style. Therefore, there is nothing more than a change in expression. Thus this is not a beneficial mutation per se. This is a change in expression of a gene in response to a change in diet not exactly ground breaking stuff is it?
If you read what I said again you will notice that this is what I said here: this is obviously due to selection bias. (Doctors only need to learn about the mutations that we will encounter, namely those that will have clinical significance.And you don't think that the fact that you were training to treat illnesses would have meant that they concentrated on teaching you about mutations that do cause illness?
I think you will actually find that the majority of early miscarriages (by that I mean less than 12 weeks) are due to major genetic abnormalities.Yes, of the small percentage of mutations that are deleterious a lot of the highly deleterious ones never make it into the gene pool due to failures in embryonic development. That is natural selection in action - something you seem to think isnt happening in humans any more.
I think you will also find that natural selection is being skewed by modern technology. For example, in previous generations the weak would have died of infections before breeding these are being treated by modern medicine such that they are able to breed. So if anything, modern medicine is contributing to a weakening of the gene pool. I dont think I would be the only person to recognise that once a species can adapt the environment and improve their survival without the need for mutations they are stepping away from natural selection.
Well, I refer you to a couple papers that would suggest that you are wrong.No, the majority of mutations are neutral. As a Doctor you are concerned with harmful mutations that make people sick, thats why your training concentrated on them.
Heredity - Estimation of spontaneous genome-wide mutation rate parameters: whither beneficial mutations?
In the introduction, Most researchers agree that mutations with phenotypic effects are usually deleterious.
The summary statement in the abstract is telling isnt it:
It is argued that, although most if not all mutations detected in mutation accumulation experiments are deleterious, the question of the rate of favourable mutations (and their effects) is still a matter for debate.
[FONT="]In the section that is titled On detecting favourable mutations...[/FONT]
[FONT="][/FONT][FONT="]Yet most experiments looking at multicellular organisms have so far failed to produce any information on such mutations.[/FONT]
[FONT="]I therefore conclude that I am not making wild statements without evidence. I had searched at the time of my university education and this is what I was finding. At the time I had full access to pretty much all the journals online thanks to King College London internet access. I lack that now. However, it is fairly easy to see that the number of beneficial mutations are so small in number as to be improbable to improve the human species.[/FONT]
[FONT="]I think that with Adam and Eve, we started with genetic perfection. Then since that time we have been accumulating mutations ever since then. The variation that we see around the world is due to the mutations of the DNA passed down to us.[/FONT]
[FONT="]So I would argue that we are not evolving up, we are evolving down. I refrain from using the term devolution because somebody would merely point out that evolution does not have a necessary direction. However, I think you can see what I am saying. The human genome is deteriorating at a fast rate. In order for this to be possible, I think that the human species is young.[/FONT]
Just so you can see that this is not an isolated source
High genomic deleterious mutation rates in hominids : Abstract : Nature
I do not have access to the full journal but surely title is suggestive of the content of the article and the background information to it:
[FONT="]High genomic deleterious mutation rates in hominids[/FONT]
Now, dont get me wrong I do not accept their idea that humans are derived from hominids, however, if experts in human genetics are making statements like High genomic deleterious mutation rates in hominids, I can say that mutations in human DNA are almost always deleterious?
I am not without evidence when I say that the vast mutations in humans are deleterious.
Gunfinger,
I suspect that a lot of what you have said has been answered above.
I have already thanked you for the link regarding beneficial mutations. However, I think you will see that I do have the backing of top geneticists that there is a high rate of deleterious mutations in humans. Therefore, although I am skewed with selection bias regarding mutations I do have published articles on the topic.You claimed that there have never been beneficial mutations. The video clearly shows that while there is little objective measure of beneficial there have been plenty of mutations that would fit into what we would consider "beneficial".
Where are the publications stating the majority of mutations are neutral?
Hmm, now is the height difference due to genetics or diet and improved child health?However, if you look up the height of the vikings based on unearthed skeletons, they were about 5'5" tall on average. So yes, human beings ARE evolving.
I suspect you will find that where there has been a substantial rise in the standard of living in a culture, the children will be taller than their parents. You will also probably find that they are wider! ;-)
As I said before, humans have got to the stage where we are adapting our environment such that a lot of changes that we see are due to us meddling with our environment or coming up with other strategies such as childhood immunisations, good sanitation etc. As an example of this (which is related to the next bit is lactose intolerance), we may find an increase in congenital lactase deficiency. They previously died as infants, now they may live to reproduce and pass on their autosomal recessive genes. Just one piece of evidence that shows that humans are getting beyond the scope of natural selection we still have selection, it is no longer natural.
Autodidact
Interesting that you assume that the ability to digest milk is new. I think you have jumped a couple steps. You would need to show that the entire population on the globe were incapable of digesting milk in previous generations. And then suddenly a small population started to be able to digest milk. The headline would read Family can now digest milk!Congratulations, you have just discovered your first of many beneficial human mutations.
However, what we see is that there are people who do not express lactase into adulthood (i.e. not long enough for their culture). They still have the genetic information, they just do not express it. So you are incorrect on this one, hence I couldnt see where you were going with this one. All that is happening is that the lactase is being expressed into adulthood.
The YEC would say that farming was present from Genesis 4 onwards. Thus, I would say that lactase was present and expressed into adulthood at the beginning. People then no longer expressed it into adulthood because of a nomadic life style. Therefore, there is nothing more than a change in expression. Thus this is not a beneficial mutation per se. This is a change in expression of a gene in response to a change in diet not exactly ground breaking stuff is it?
Er, Autodidact you say The fact that you dont already know this I DID know this. I mentioned it because otherwise people might underestimate the harmful mutations. It is a significant number of harmful mutations that are not recognised by non-medics. It consumes a significant amount of energy such that if it is not factored into the equation of harmful vs benefitial mutations, you will end up with an inaccurate result.Yes, there are, and, as ToE explains, as a result they die out and do not spread throughout the population. The fact that you don't already know this is the sort of thing that is causing us to doubt that you ever actually studied ToE.