DNA does not work in any solvent except water. Why is that and what is the significance? DNA evolved in water with water always the majority component of life, defining natural chemical selection at the nanoscale. Water is not tuned to DNA, DNA is tuned to water, allowing DNA to work properly.
If you mix water and oil and agitate, you will get an emulation; chaos. If are allow this chaos to settle, order will appear. We will slowly get bubble and two phases; layers, which will separate out. This reversal is not random. Water allows order to appear from apparent chaos of the emulsion. We need to add energy to make the two phases of water and oil, random; an emulation. Water wants to lower the surface tension and shed this added energy, and in doing so allows order to reappear.
Life is made primarily of water and organics, with the majority component; water, forcing the organics to phase out into various distinct organic phases; organelles. Once phospholipids molecules formed in water, there was only one way to minimize surface tension, between the water and "this oil". We call this a lipid bi-layered membrane. It still happens every time, because the dice are loaded by water. The casino science odds makers do not yet understand how water loads dice and counts cards. This must seem like magic to them.
DNA was a logical consequence of the interaction of the organics of life (oil) and water. When water forces any oil to phase separate, it does so in a way to minimize surface tension, by minimizing surface contact area. A sphere is a minimal surface for any volume; bubbles. However much we minimize, the remaining contact surface area is an energized surface. How does water deal with this last bit of energy? An energized surface has extra energy for change, with the goal to lower and lower surface tension. Organics can form endless combinations; variety of molecules, with some better for lowering the residual surface tension; water selects protein for the membrane.
DNA is a very hydrated molecule, with lots of water attached. There is a double helix of water in the major and minor grooves of the DNA or organic double helix. DNA sort of defines a state where organic and water become almost one, in terms of shared potentials. The DNA is soluble in water, but it is also a very large macromolecule that also appears to be insoluble, since it does not disappear, like salt or sugar, due to its huge size. It is sort of the logical result of the surface tension of the 3-D sphere; oil bubble, flattening al the way a 1-D line; almost minimal surface tension, where they become one composite thing.
When protein fold and pack, to minimize surface tension in the water, the hydrophobic cores are isolated from the water. All the water will see are the protein surface area. But DNA can stay fully exposed, unless you add packing protein, thereby adding extra surface tension in water, so the DNA-protein composite has to fold; bubble up. Unpacking the chromosomes, allows the naked DNA, in part or full, to be an extension of the water, so the DNA can be become integrated to all the organics via the continuity of the surface tension in the cellular water; integrated organic cellular differentiation.