The problem with this stance is that without knowing the full nature of existence we can never know how accurate or inaccurate what we THINK the nature of existence is, now, is.
It's funny that after reading this I pictured Dory from Finding Nemo, with her singing her mantra, "Just keep swimming, swimming, swimming ..."
All I would say is that it is not a problem with the stance, it is simply the nature of the problem that humanity has been trying solve since the very beginning.
Just in terms of cosmology, it is estimated that we know only about 4% of the physical universe. Which is a percentage so small that it is of no consequence at all given the much greater probability of error. So when we presume that we "know things" about the universe, it is entirely a pretense based on our self-centered bias/need to imagine that we understand the world we exist within, and can therefor control it to our advantage. When in fact we don't really understand or control it at all.
I would say that here, you have things the wrong way 'round. Not regarding our limited access to only 4% of the physical universe, whatever the actual percentage might be. It is the notion that it is a self-centered bias to imagine we understand the world we exist in, when in reality, it is a self-centered bias to presume to know what lies within the unknown, beyond our understanding of the world we exist in.
I think you fail to appreciate that as our understanding has grown over, say ... the last 100,000 years, all that increased understanding has only clarified our understanding of the same old physical world we live in, while at the same time only swept away all our imaginings of what lay outside of our understanding, what resided in the unknown. No gods above the clouds nor demons under our feet.
Given this long track record, the stance I advocate and which you see as problematic, is actually working. We simply have to accept that there is no jumping to the end of this process.
I recognize the logic of 'going with' the information that we have, even as little as there is of it. What choice do we have?
Thanks for the recognition, and yes, to date there is no other choice.
But what I obect to is the overwhelmingly prevalent and dishonest assertion that what we think we know, is what is so. Because in truth, we have no logical way of establishing that as a fact.
I do appreciate your objection here up to a point. We are fallible creatures after all, requiring constant vigilance in maintaining course. I also appreciate your philosophy of enabling possibility. But dismissing what we hold in high confidence because we can't see it in relation to the (as yet) unknowable whole I see as a mistake. Isaac Newtons Classical Mechanics wasn't the whole story, nor is Einstein's Relativity the final word, but both brought better understanding to the physical reality we experience, which hasn't change. I would say presuming there is something more and better just over the rainbow prevents us from acknowledging that how we live and interact in the world it up to ourselves. If we are collectively unhappy with the current state of affairs, then we must look to ourselves to make the required changes. Stop waiting for something to be revealed beyond the rainbow, roll up our sleeves and take charge of the present and foreseeable future.