I don't think you've quite gotten it. Science doesn't have a stance on the validity of untestable hypotheses. It may seem like we are splitting hairs here, but when you declare the hypothesis to be 'not valid' because of the absence of an experiment that tests for it, you simply are not doing science. Science does not assert the invalidity of hypotheses that it does not test for.
Actually, science does take a stand on untestable hypotheses: it declares them to be un-scientific. And such hypotheses *should* be considered with a great deal of skepticism: it is trivial to come up with multitudes of untestable ideas that should be immediately rejected. For example, perhaps angels are what drives the planets instead of gravity: they just do it in exactly the way gravity would.
We agree that it isn't included in science and the reason it isn't included is because a scientific hypothesis must be testable (or falsifiable). And yes, Ockham's Razor does say the hypothesis is unnecessary. But that is not an assertion about validity of the hypothesis. This is the point we are odds with each other about.
But the fact that it is unnecessary and untestable *should* put it under a cloud of suspicion. Again, it is just too easy to come up with untestable ideas.
When you say the hypothesis is invalid, then you've gone outside of science in order to make that claim. You're doing something else that isn't science. So you cannot claim your assertion is supported by science. This is what it seems to me that you are trying to do.
Anyway, to bring things back to the question of what is random. I think science uses the term random in reference to certain things beyond control (or prediction). And that intelligence, as understood by science, is a human phenomenon. Whether or not there is an intelligence (or supernatural intelligence), science is going to refer to the events such as mutations as random. Science can even refer to a car being driven through a an intersection by a conscious intelligent human as random if it is outside the scope of control and prediction, yet can influence the outcome of an experiment or the occurrence of an event. For example: someone is measuring the wind speed at the intersection and his results are subject to the random appearance of cars that pass through the intersection.
Randomness is a matter related to observation.
I think there are two types of 'randomness' that are common in science.
The first is where we don't know or don't care about the causes involved because the specific origin doesn't matter at the level of detail we are considering. So, in mutations, the cause may well be a chemical in the environment or a cosmic ray and the action on a specific DNA site may well be fairly specific. But only slight changes in conditions would lead to a very different mutation (different cell hit by the cosmic ray, different location on DNA changed, etc). This sensitive dependence on initial conditions means that it is impossible in practice to predict what mutation will happen, even though theoretically it might be possible if we had perfect knowledge and perfect models with accurate enough computability.
This seems to be the type of randomness you are focusing on and it *is* the typical aspect of randomness seen. Pretty much all of classical statistical mechanics is of this sort, for example. This is the type of randomness that happens when we toss a coin or throw dice. We *could*, given sufficient time, accurate information, and computing power, predict the results, but we don't want to go to that level of detail.
But, the type of randomness in quantum mechanics is of a different sort. Instead of an approximation obtained by ignoring aspects that are too difficult to compute, QM *is* the basic theory. And what the basic theory predicts is probabilities, not specifics. Even if we had perfect information about initial conditions and all the computing power we could want, the basic theoretical description *on a fundamental level* is probabilistic. There is randomness at the heart of the theory itself. And, based on all we know, in this regard any fundamental theory will have this aspect in it (yes, it is always a danger to make statements like this).
This is NOT a randomness because we are ignorant of the causes. It is not a randomness because we want to ignore the details for simplicity. It is not a situation where our instruments just aren't good enough. It is something about the basic structure of the universe at the quantum level. The randomness is written into the theory. And the theory works.