Ketamine (2-(2-chlorophenyl)-2-(methylamino)-cyclohexanone)
Ketamine is used as a veterinary anaesthetic. It has not been shown to be damaging to the human mind or body when not used in excess chronically. It is addictive and there is a withdrawal effect, however.
DXM (Dextromethorphan)
Dextromethorphan is found either in a hydrobromide salt or in a polisterix plastic bond. Dextromethorphan is used as an ingredient in cough medicines. However, DXM is a powerful dissociative at higher doses. It has not been shown to be damaging to the human mind or body when not used in excess chronically. It is not considered addictive (although there are reports of minor psychological addictions) and there are no withdrawal effects.
[FONT="]PCP (Phencyclidine)[/FONT][FONT="]
Phencyclidine is the most dangerous of the three commonly abused dissociatives. It is addictive, has been shown to be damaging when used in high amounts or in low amounts chronically. PCP also has a very unpleasant withdrawal effect. Under the effects of phencyclidine, some people have a tendency to become violent, and because phencyclidine numbs the association of the mind to the body, physical pain will be much less of an obstacle.
Nitrous Oxide
Nitrous oxide is an inhalant. Almost all inhalants have been shown to be highly neurotoxic (damaging to the brain) and dangerous for the body. However, there are a few inhalants that have never shown danger to the mind and body when used responsibly. Nitrous oxide is one of them, along with diethyl ether (used as a replacement for alcohol before Modern Prohibition), and butyl/amyl nitrite. Nitrous oxide produces a short lived (several minutes) extremely powerful high with quite a lot of euphoria. The only dangers of nitrous oxide are not getting enough oxygen (Care must be taken to ensure that oxygen is received if a nitrous oxide breathing mask is being used. If whippets, or nitrous oxide canisters, are used, this is much less of an issue) and vitamin B-12 depletion. People who use nitrous oxide regularly would be wise to take vitamin B-12 supplements, as nitrous oxide has been shown to deplete the bodys stores of this vitamin.
GHB (Gamma-hydroxybutyrate)
GHB is a drug very similar to alcohol in effect, but without a hangover or the negative effects that alcohol commonly produces. However, GHB is also addictive and extremely easy to overdose on. I would like to note, however, that GHB is only easy to overdose on because it is a black market drug. Were it sold in pharmacies, doses would be pre-measured and accurate. GHBs withdrawal effects are dangerous, but not nearly as dangerous as alcohol. Recently GHB has received attention by some in the science community as a potential antidepressant. Experimental and anecdotal reports have indicated that GHB may be a powerful antidepressant, better than any other on the market.
Kava kava (Piper methysticum)
Kava kava is a drug that some compare to alcohol. It is not illegal to possess, although it is illegal to consume in [/FONT][FONT="]Canada[/FONT][FONT="]. It has not known whether or not kava kava is addictive or whether it has a withdrawal effect.
Opium (Papaver somniferum), Opiates, and Opioids, including:
Opium is the milky latex collected from the seed pod of the common plant known as the opium poppy. Opiates are naturally derived and opioids are synthetic.
Heroin (Diacetylmorphine)
Heroin, the oft despised opiate, is actually not at all damaging to the mind or body. No study has ever shown detrimental physical or mental effects caused by heroin. There is simply no such causal link. However, that does
not mean that heroin is not dangerous. It is. But its danger comes from a different source: Addiction, withdrawal, and overdosing. Heroin is extremely addictive, both physically and mentally. However, addiction does take some time to be felt, and, conceivably, one could have a once or twice a month heroin habit and never feel the effects of addiction or withdrawal ever. Heroins withdrawal effects are severely painful and may require hospitalization but will not cause death. Overdosing is a big problem with heroin, but this is simply because street heroin has no known purity and it is difficult to test for purity (for the layperson, anyway). Each time a heroin-user buys heroin, they should, at the absolute least, test the potency of the heroin by using an extremely small amount before full dosing.
Fentanyl, Hydrocodone, Meperidine, Oxycodone, and other prescription painkillers
These opioids are prescribed commonly for pain. Hydrocodone is the lowest on the scale of effect, followed by meperidine, oxycodone, and then fentanyl. All of them have addictive potential and all of them have withdrawal effects. However, like heroin, there is no real damage caused to the body or mind.
Phenethylamines, including:
2C-B (4-bromo-2,5-dimethoxyphenethylamine)
2C-E (4-ethyl-2,5-dimethoxyphenethylamine)
2C-I (4-iodo-2,5-dimethoxyphenethylamine)
2C-T-7 (4-propylthio-2,5-dimethoxyphenethylamine)
All of the above phenethylamines are research chemicals, or RCs, and not enough is known about them for me to list any of their effects on the body or mind. It is not known whether they are addictive or whether they have a withdrawal effect, however, these drugs are psychedelics, and therefore are probably not addictive and probably do not have a withdrawal effect.
Ephedrine (Ephedra)
Ephedrine is a stimulant, and is addictive with a moderate withdrawal effect. The highest danger in ephedrine use is the increase in blood pressure and heart rate. Those who already have high blood pressure or heart rates, or weak hearts, should never use ephedrine.
MDMA (3,4-Methylenedioxy-N-methamphetamine - ecstasy)
MDMA is dangerous on the street because it is often cut with many other chemicals. When used in pure form, it is relatively safe. However, weekly, biweekly, and maybe even monthly use can cause reversible brain damage (once use stops the brain will recover). The safe use limit has been estimated to be between 4 and 12 uses per year (Dr. Shulgin and others). When MDMA is used the brain is flooded with its serotonin stores, and the user experiences deep feelings of love for all people and things as well as euphoria and empathy. MDMA has been found to be highly effective in couple-therapy. It has been known to produce life-changing experiences. It is not physically addictive and there is no withdrawal, but it is psychologically addictive (users can come to be addicted to the feelings it produces if they use it too often) and there may be a mild depressant effect for one or two days after use, as your body rebuilds its serotonin stores.
MDEA (3,4-methylenedioxy-N-ethylamphetamine)
MDEA is almost exactly the same as MDMA; there are very few differences. It is considered more psychedelic than MDMA. Addiction, withdrawal, and dangers are the same.
MDA (3,4-methylenedioxyamphetamine)
MDA is the precursor to MDMA, and it too is very similar to it. Again, it is considered more psychedelic than MDMA. Addiction, withdrawal, and dangers are the same.
Mescaline (Peyote and other cactii)
Mescaline has been used religiously for millennia by southern Amerindians. It is found in the peyote cactus (which takes approximately 27 years to grow before it can be used), the san pedro cactus, and the Peruvian torch cactus. The latter two are used far more often as they grow enough to be used within a year or two. Mescaline itself is not addictive, has no withdrawal effects, has never been shown to be neurotoxic or damaging to the body. Indeed, I see no reason why mescaline would be illegal, other than political reasons (Modern Prohibition, Ive found, is largely a political game).
[/FONT]