One main difference between the macro world and the quantum world is, the observation of the quantum world, has more of an impact, on the quantum world, than does observation of the macro world have on the macro world.
The largest and most energy intensive tools of science; particle accelerators, deal with the smallest things; CERN. These tools have an impact on the observation, since they add energy that can alter the observational entropy of these tiny things. Even if we assume CERN is 99% efficiency, that means there is still about 2 megawatts going into experimental entropy, continuously. There is a good chance we are altering the natural information, of tiny things, into synthetic information with higher entropy; new states of matter.
On the other hand, if I stick a thermometer into a breaker of the water, the impact of my experiment is much smaller and therefore more accurate with respect to reality. On the other hand, a quantum level experiment at CERN, even if repeatable, would still add the same entropy, leading to the same altered states, thereby leading to a consistent artificial result, assumed to be natural. Theory deals with altered data.
Another series of assumptions, that I read about quantum thermodynamics was they equated entropy to information and that universal information was conserved. If you think of it, this assumption of information conservation is the same assumption behind the idea of eternal souls in religion, since the soul is eternally conserve personal information. The theory is borrowing from religion, without even realizing it.
Another problem, which is also connected to information, is the direct information we receive from the universe, from which we infer all theories in cosmology, is all based on energy signals. Almost none of the informational data is based on direct contact with matter and mass. This can cause the problem of assuming an energy based mirage reflects tangible reality, with no direct way to touch the mirage, other that assume the mirage is consistent with assumptions and theory. Dark energy fits into that category.
With respect to chemistry and entropy, one is dealing with tangible things with the experimental results often used by applied science, to manipulate other tangible things, to make new tangible things, helping us verify this is not an energy information mirage of tangible things. I like the classic chemical entropy theory because it is based on tangible things that are less influenced by experimental entropy inductions and mirage based assumptions of tangible things.
Common sense would say that a quantum interface to thermodynamics needs to use the tangible macro data as the baseline, since this data is less impacted by informational energy mirage and experimental entropy. It is also the preponderance of data in all of science, There is more data about water than anything else. Going the other way, could be useful in situations, like computers, where processor energy is altering entropy of quantum states, into new states, we need to deal with. But if bulk reality, as is, is important, classical has a better data baseline for natural; as is. Extrapolation from this base is a better way to deal with cosmology.