First. The thread title is "The wisest man in the world is the one who realizes he knows nothing". I do not see that the thread has anything to do with this deep spiritual knowledge. In my understanding, it is the description of Heart Sutra. It is the description of Yoga - union with the non dual whole. In 'samadhi' there is nothing to know about. There is nothing except awareness. I do not know why you titled the thread the way you did.
Second. I am a geoscientist who knows and has directly seen the paleontological, palynological, and geochemical evidences that indicate increasing diversity and complexity of forms of living organisms through geological ages. I do not think that many fundamentalist so-called science lovers here have such direct experience of TOE. The point is that I have no need to poke holes in TOE -- I am a propagator of this knowledge. But, TOE is about evolution of life forms. It is not about origin of life. Some so-called scientists extrapolate TOE to generation of 'conscious living beings' without any evidence. And some fundamentalist so-called science lovers offer these hypotheses as proof against spiritual wisdom in blanket fashion. TOE does in no fashion contradict the knowledge of Vedas and Upanishads, wisdom of which operate in a different scope.
For example, in science too, Newton's laws are correct within a scope. TOE is applicable within its own scope. Upanishadic knowledge is applicable in a different scope and serves a different purpose. I operate as a scientist within a limited scope but I am also a meditator who believes (not without reason) that attaining the experience and knowledge of objectless existence, which is the subject of 'Heart Sutra' and similar other scripture is the summit. Similar are many other layers of spiritual and religious knowledge, which serve as positive purpose in lives of many.
Some so-called scientists and so-called philosophers tag anything and everything spiritual as mere belief. They simply do not know. And there lies the contradiction.
I think you understand why.