I never ignore anyone, but I have no problem compartmentalizing people's opinions as basically irrelevant to me in any meaningful way, unless it's an opinion I can respect.
I think some people are better off using the ignore feature - particularly those who feel real and actual emotional/psychological distress from reading what somebody posted online.
At the end of the day, if people can bother you, you're probably better off using the ignore (or avoiding the internet altogether) - if you can easily brush off annoying or offensive people, then why bother with the ignore feature? These are often the people who provide the biggest (unintentional) laughs as well.
This sums up my view as well.