If you believe in science, evolution, and natural selection then two sexes; male and female, is the only conclusion that is totally consistent with this theory. The theory does say that there will be mutations and other distinctions in nature, but ultimately, evolution and natural selection involves procreation; passing forward the best genes.
Most of the extra sexes of the mind, can't procreate, unless they revert back, in some way, to the standard male and female roles. Such people can still thrive as individuals, but evolution is also connected to procreation. Procreation is where genes, which have the traits, are conserved via the DNA. If you were a male who thought you were a female, you male based sperm, has your traits ingrained as genes. The female side of does not contain this.
If you look at this logically, the philosophy of extra sexes, beyond two, uses a modified Creationists philosophy; type of religion, instead of an evolutionary philosophy; science. They will use science and politics, to play god, so they can rig the parameters of nature, using various legal, science and free market prosthesis magic tricks. If the magic is good, people get fooled.
For example, say there was a three legged toad, with all three legs different sizes. In a natural environment, he would not be selected for procreation, but would quickly become a food based mutation, for slower critters.
But if you get humans involved, who wish to play god; atheists, they can set up tricks to cheat nature and natural. They can set up a large glass pen full of easy to get resources, using laws and technology. They can even allow the toad to breed, through artificial insemination, so it has offspring, so it all looks like natural selection. If we also invested $millions and it became a reality TV celebrity, then selection becomes fully based on human prestige. But if we removed all the prosthesis, then natural reality becomes clear.
Say you went to a magic show and the magician's lovely assistant levitates around the stage. The trick is done very well and you cannot see how it is done. Some people, who lack science knowledge and/or who have faith in the mysterious, will start to believe levitation is possible. They saw it happen, and this can be verified by everyone on the room, just like in science.
Others, who have a more skeptical science bent, may not be able not prove it, but they know this cannot be real, since anti-gravity is way in the future. They know this is a trick; manmade creationism, but they are still trying to figure it out in a room where most people have been fooled. I am showing you how the trick works, so you can have the option to believe in the man made creationism, or remain grounded in evolutionary science reality.
The Vatican has relied on Evolution Science, to disprove man made Creationism. Vatican says gender theory is an attempt to annihilate nature or natural with man made creationism. Separation of Church and State may need to be evoked. In other words, you can practice your faith in the private sector, but the governments needs to stay out of it; all such law needs to be revoked. This will cripple the magic show and will be resisted by the magician union who will instant manmade creationism is free market and not religion.
A magician uses science and technology to fool the eyes, so the mind thinks it has gone beyond the natural. The audience, if fooled to believe, has been transported to an alternate reality. The magician is providing a fantasy service, but the audience, by being fooled, can be induced into a religious state of mind.
The compromise may be a legal disclaimer, by the magicians, that say this is a trick and is not natural or super natural, but is intended for entertainment only. On the other hand, the hack magicians can be more effective if the audience believes in the magic of better magicians, in advance; religious primer. The disclaimer may still be enough.