I'm sure I have way more than 10, but here's the ones off the top of my head:
1) Make sure everyone here has all the basic necessities of a civilized and prosperous nation, like healthcare.
2) Fix our immigration system so that it is fair, non-discriminatory and does not divide/separate families.
3) Stop turning this country into a police state. Police/Law enforcement have way too much authority and far too many of them abuse that authority on a regular basis and the poor soul that falls victim to their abuses have virtually no say, rights or ground to stand on, despite claims to the contrary. On the flip side, stop letting people like child-rapists/murderers get through the cracks of justice like we do currently, only to have them do it again. If they do, promptly put that person out their misery, preferably by the parents.
4) Have America live up to it's title and have this place be a little more "free" than what it currently is. Outlawing something like happy meals being sold at McDonalds because they're unhealthy, is going way too far. Getting rid of the Patriot Act also goes hand-in-hand with this. There's too many redundant and unecessary laws that are there just to create revenue for the state government at your expense.
5) Make gay marriage legal. If individual churches don't want to marry gay people, that's their perogative, but marriage is not exclusive to religions.
6) Stop outsourcing all of our damn jobs to foreign countries for dirt-cheap labor, getting around regulations, tax breaks etc. YOU are what is destroying the job market in America, not illegal immigrants.
7) Regulate Wall Street, the housing and bank sectors, insurance companies, etc, properly. We've seen what happens when we let these clowns that are "the private sector" regulate themselves: Uncontrolled greed at everyone elses expense. We do not need anymore economic meltdowns, thanks.
8) Start having the FDA start taking a serious look at natural or low-cost cures for disease like cancer, instead of having sit in clinical trial-limbo because drug companies can't get a patent on them and make tons of cash. Also, stop pumping our food full of chemicals, hormones and various other unnatural crap that is made by some of them same companies previously mentioned.
9) Get serious about perserving our enviorment and stuff like global warming. It's a serious problem and it's not going to go away just because some people want to ignore it.
10) Only send military into foreign countries if those people really need our help. Don't send them there for special interests (like oil) that are anything but stopping the bad guys from causing harm to others.