There is nothing inherent in brain or its functions that is equal to "I" sense, which is the subject and the seer of brain and its states
In my view the evidence the other way is overwhelming. Its most basic statement is, no brain, no self-awareness.
Why is it so difficult to acknowledge that we do not know the source of "I" sense, how it comes about and how it ceases.
I acknowledge that at this time we don't have a description of the generation of self-awareness in the brain. However, your argument appears to claim that the origins of self-awareness are unknowable in principle, and I see no basis for that. We continue to explore and describe brain function, and to explain how it works, and we've made remarkable progress since better tools became available in the 1990s. The gaps in our knowledge are there to be filled in, not to be regarded as the demonstration of failure of the method or end of the story.
Correct me if I'm wrong, but you view does not offer any evidence-based explanation at all of how self-awareness arises, does it?
materialists have a-priori decided that only that which is manifest to senses is true
More exactly, is capable of being shown to be true.
it cannot even postulate a seer of the mind-sense modification.
If there were examinable evidence for a real seer, there'd be no problem.
Whereas, observing the continual changes of the mind-sense constitute the primary witnessing in Buddhist and Hindu yogic practices. ...
But by what means do they demonstrate that their conclusions are accurate statements about reality?
The yogic paradigm does not negate or obstruct science. It has no conflict at all.
It accepts that self-awareness is the product of brain function then?
Whereas, materialistic paradigm has been proven wrong again and again with new scientific discoveries.
Yes, of course. Since there are no absolute statements, that's inevitable. Not only that, but repeating our experiments, often with variations, and retesting our conclusions, is a required part of the method ─ indeed, the appetite and the ability to self-correct are two of the strongest aspects.
Materialism only shifts the goal post when science shows that the concept of solid reality is not valid.
I don't understand your objection.
If science used to think A is the case but now finds B is the case, why should science not proceed on the basis that B is the case?