Most of you remind me of victims on a steadily sinking ship all scarpering for the life boats. The Titanic did sink. If you were not so ignorant you would know there are many scientific papers that say the same as my chosen articles. You're being petty and ignorant of the holistic body of evidence. It is rather idealistic to ignore all the research. It's called arguing with blinkers on.
Re utube video evidence...and still scientists do not know what they are looking at if you read the info below ... I expect you'll find the same similarility in a sponge if you look hard enough!!!! Various species can be infected by similar virus as the last article here shows. It does not necessarily mean anything. Next please....
Retrovirus Replication Process Different Than Thought
ScienceDaily (July 15, 2010) — How a retrovirus, like HIV, reproduces and assembles new viruses is different than previously thought, according to Penn State College of Medicine researchers. Understanding the steps a virus takes for assembly could allow development of a way to prevent the spread of retroviral diseases.
The start of the replication process is the production by the retrovirus of a protein called Gag. Prior to this study, it was thought the building process happened outside the nucleus in the cyctoplasm -- the material that fills the cell -- and then Gag protein was sent to the plasma membrane -- the outer boundary of the cell. The researchers discovered, however, that Rous sarcoma virus takes a detour through the cell nucleus before going to the cell membrane.
The Gag protein has a signal, which tells a receptor to take it into the nucleus. Once in the nucleus, Gag binds to the viral RNA. The viral RNA alters the structure of the protein, changing the way it folds. This new configuration triggers a different signal that allows the Gag to move out of the nucleus.
"There's a sequence of events that has to happen in a very specific order," Parent explained. "The Gag protein has to find its own RNA, build a virus particle around it, and then release it from the cell." Finding the viral RNA is the first committed step in the assembly process. By focusing on regulatory processes in assembly, researchers are looking for key events that, if disrupted, could stop the virus from spreading.
"We want to understand the smallest building blocks of the virus particle," Parent said. "If we interfere with the first step, the virus will never be released from the cell. Cells are complex, so we use the key elements in a test tube to figure out how Gag and the RNA interact."
This study built on a 2002 paper, which proposed a model for the Gag protein's entry into the nucleus. The researchers reported in the Proceedings of the National Academy of Sciences that Gag does travel in the nucleus. Further study will examine how the Gag complex travels from the nucleus to the plasma membrane.
Human Cells Can Copy Not Only DNA, but Also RNA
ScienceDaily (Aug. 10, 2010) — Single-molecule sequencing technology has detected and quantified novel small RNAs in human cells that represent entirely new classes of the gene-translating molecules, confirming a long-held but unproven hypothesis that mammalian cells are capable of synthesizing RNA by copying RNA molecules directly. The findings were reported in Nature by researchers from the University of Pittsburgh School of Medicine, Helicos Biosciences Corp., Integromics Inc., and the University of Geneva Medical School.
"For the first time, we have evidence to support the hypothesis that human cells have the widespread ability to copy RNA as well as DNA," said co-author Bino John, Ph.D., assistant professor, Department of Computational and Systems Biology, Pitt School of Medicine. "These findings emphasize the complexity of human RNA populations and suggest the important role for single-molecule sequencing for accurate and comprehensive genetic profiling."
Scientists had thought that all RNA in human cells was copied from the DNA template, Dr. John explained. The presence of mechanisms that copy RNA into RNA, typically associated with an enzyme called RNA-dependent RNA polymerase, has only been documented in plants and simple organisms, such as yeast, and implicated in regulation of crucial cellular processes. Since thousands of such RNAs have been detected in human cells and because these RNAs have never before been studied, further research could open up new fronts in therapeutics, particularly diagnostics, Dr. John said.
In the study, the researchers profiled small RNAs from human cells and tissues, uncovering several new classes of RNAs, including antisense termini-associated short RNAs, which are likely derived from messenger RNAs of protein-coding genes by yet uncharacterized, pervasive RNA-copying mechanisms in human cancer cell lines.
"This class of non-coding RNA molecules has been historically overlooked because available sequencing platforms often are unable to provide accurate detection and quantification," said Patrice Milos, Ph.D., chief scientific officer at Helicos Biosciences. "Our technology provides the platform capability to identify and quantify these RNAs and reinforces the potential clinical advantages of our single molecule-sequencing platform."
ScienceDaily (Oct. 12, 2007) — According to paleontologic and molecular studies, the chimpanzee (Pan troglodytes) is the closer relative to the humans (Homo sapiens) and that both lineages had a common ancestor at 5 to 7 million years ago.
Moreover, the human-chimp lineage split from that of the rhesus monkey (Macaca mulatta) around 25 million years ago. However, by studying the population dynamics of complete copies of primate endogenous retrovirus family K (ERV-K) in the genomes of humans, chimpanzee and rhesus monkey, a surprising pattern was observed.
The study by Romano and colleagues being published this week on PLoS Onerevealed that human ERV-K had a similar demographic signature to that of the rhesus monkey, both differing greatly from that of the chimpanzee. The data suggested that the humans and rhesus have been purging ERV-K copies from their genomes while the chimpanzee ERV-K population kept the signature of increasing numbers of ERV-K amplification in the genome of ancestral primates during the last 20 million years.
Identification, characterization and comparative genomics of
chimpanzee endogenous retroviruses
Nalini Polavarapu, Nathan J Bowen and John F McDonald
Abstract
Background: Retrotransposons, the most abundant and widespread class of eukaryotic
transposable elements, are believed to play a significant role in mutation and disease and to have
contributed significantly to the evolution of genome structure and function. The recent sequencing
of the chimpanzee genome is providing an unprecedented opportunity to study the functional
significance of these elements in two closely related primate species and to better evaluate their
role in primate evolution.
Results: We report here that the chipanzee genome contains at least 42 separate families of
endogenous retroviruses, nine of which were not previously identified. All but two (CERV 1/
PTERV1 and CERV 2) of the 42 families of chimpanzee endogenous retroviruses were found to
have orthologs in humans. Molecular analysis (PCR and Southern hybridization) of CERV 2
elements demonstrates that this family is present in chimpanzee, bonobo, gorilla and old-world
monkeys but absent in human, orangutan and new-world monkeys. A survey of endogenous
retroviral positional variation between chimpanzees and humans determined that approximately
7% of all chimpanzee-chimpanzee INDEL variation is associated with endogenous retroviral sequences.
Conclusion: Nine families of chimpanzee endogenous retroviruses have been transpositionally
active since chimpanzees and humans diverged from a common ancestor. Seven of these
transpositionally active families have orthologs in humans, one of which has also been
transpositionally active in humans since the human-chimpanzee divergence about six million years
ago. Comparative analyses of orthologous regions of the human and chimpanzee genomes have
revealed that a significant portion of INDEL variation between chimpanzees and humans is
attributable to endogenous retroviruses and may be of evolutionary significance.
Newhope101 states....The operative words in the above article are 'May be".....the fundamental basis for ToE.