So what deep significance do you attach to
this?
And do you have examples of " theorizing"
about things for which no relevant lab work has
been done or is even possible?
For me personally, the signifance would depend on what the particular topic is. I.e. the area under study. For example, I have a personal fascination with the research into how toxins evolved in Dendrobatidae / poisen dart frogs. One of the studies done on the topic titled,
"The evolution of coloration and toxicity in the poison frog family (Dendrobatidae)" addresses elements of this topic. As they stated about their research:
These frogs generally have been considered to be aposematic, but relatively little research has been carried out to test the predictions of this hypothesis.
So, according to this study, prior to their work relatively little research had been carried out to test the predictions of this hypothesis. They further stated,
Here we use a comparative approach to test one prediction of the hypothesis of aposematism: that coloration will evolve in tandem with toxicity. Recently, we developed a phylogenetic hypothesis of the evolutionary relationships among representative species of poison frogs, using sequences from three regions of mitochondrial DNA. In our analysis, we use that DNA-based phylogeny and comparative analysis of independent contrasts to investigate the correlation between coloration and toxicity in the poison frog family (Dendrobatidae).
After performing thier study, they were clear about what was apprent in thier findings and what shortcomings existed. I.e. areas for further study.
There was a significant association between the evolution of coloration (as rated by human observers) and the evolution of overall toxicity (as quantified by toxin diversity, quantity, and lethality)..............The evolution of aposematism has received extensive attention in the literature. However, few comparative analyses controlling for phylogenetic effects have been carried out to test a basic prediction of the theory of aposematism, that more toxic species will advertise their toxicity more conspicuously, with brighter, more extensive coloration. The poison frogs provide a good opportunity to test this prediction because of the wide variation in coloration and toxicity within this family. Our phylogenetic analysis provides information on evolutionary relationships that is crucial for comparative analysis. The measures of both toxicity and coloration used in this study were fairly crude. Despite this lack of precision, which could obscure any relationship between these two variables, variation in toxicity explained a significant amount of variation in coloration under each combination of measurement technique and model of evolutionary change. It is certainly possible that other selective factors have influenced the evolution of coloration in these frogs. Nevertheless, our results suggest a substantial role for toxicity in the evolution of bright coloration in the poison frogs.
This is one example of what I mean. This study was from 2001, but at a certain point, testing of this nature was limited or had not yet been performed. This study presents some level of study, like others, with the need to perform additional work.
Just, to be clear. What I wrote
Post 39 has to be taken in its entirity. I am open to the fact that all of this depends on what the particular area of study is even under consideration.