Well, you are a skeptic, so you know that universal skepticism is one way to do it.
Let me explain it.
You have 3 people.
One like you who claims to know what the universe is as W and not Z. (Stands for different facts)
Another one who claims to know that the universe is Z and not W.
Well, one of them don't know what the universe is, but is still in the universe, right?
Well, it then follows that you don't need to understand what the universe is to live in it. You just have to have beliefs which to you appear to work. They don't even have to true, just appear to you to work.
I am the 3rd person. I don't know what the universe is.
Which is why the scientific method is so important: test those ideas, trying to show them *wrong*. If you consistently fail, then they 'work' in the sense required for science. Refusing to test the ideas or adjust beliefs based on those tests doesn't lead to ideas that 'work' in the relevant sense.