As far as we understand everything is composed of energy.
Therefore isn't monism scientifically proven?
Mono means one, so mono-science would imply a type of unified theory of science that could explain everything. Energy is sort of like such a variable, but energy alone lacks the details. Polytheism was connected to many gods, therefore poly-science, would be composed of many specialty sciences, that do not fully interface each other, but like the gods of polytheism, were often unrelated and/or in conflict with each other. In science, there are often more than one theory for the same specialty things; cosmology and psychology, which is also poly poly-science.
The main symptom of poly-science is specialization which can lose track of the ideal mono-science forest, because of the specialty trees. We would need a more generalist science education and approach to science, so condensation of all the sub-theories of science, have a chance to merge into a unified science theory.
For example in climate science, everyone is fixated on a few gas molecules like CO2 and methane in the atmosphere. These are important but this is overly simplified, so you still need a dice approach for support; probability function. A mono-science approach would also consider the inner earth; core rotates faster than the surface, as well as the surface forest fires and bio-decomposition, the atmosphere and even the surface water and moving geology, among other things.
Water exists in many phases, even at the conditions inside the earth to the core, as well as on the surface and atmosphere. There is lots of water in the mantle. Water is also the majority component of life, which has an impact on the surface. Water would be a good integrating; simplifying variable, since it touches all of the rest.
Biology is fixated on organic differentiation which gets very specialized. Water in life, on the other hand, touches everything in life and therefore could be used as an integrating variable. No organics of life works properly without water assistance. Water has a unique feature of dis playing both polar and covalent hydrogen bonding; binary switch like computer memory. If we take one hundred water molecules; 2n, these switches in combination can can express any organic situation; mono-biology. Advance and speedy simulation is possible.
There is resistance to mono-science, since many small fish in many small ponds can have more collective prestige, than the same number of small fish in one big pond. Human nature would also need to be taken into account, since humans decide which approach to take for reasons beyond just science; good jobs and promotions. Even science based business patents and proprietary information is more about differentiation into free market polytheism niches, instead of integration into unified approaches. It is about the company that stands out and sells. Integration may be counter productive to the competitive model.