So what is the problem during the times when the Republicans are running the country?
In a nutshell: Government, media, legal, and educational capture, capture; in promotion of corporate interests.
Just off the top of my head:
Suppression of social and technical progress, and of research projects that might produce inconvenient results.
Defunding of social, safety, and protective programmes and agencies.
Replacement of directors and and researchers involved with said programmes and agencies with directors inimical to their missions.
Manipulation of the democratic process in furtherance of corporatism, banking, oligarchy, monopoly and the interests of the 1%.
Deregulation and "free trade" in support of same.
Reduction of the middle class, and of opportunity and social mobility, promoting a large, needy workforce..
Media capture and propaganda; taking advantage of legitimate fears and grievances, by blaming liberal policies, immigrants, religious and social minorities.