One thing that has been giving some steam to keep up with Mass Effect is decisions in the first game effecting the later games. As far as games go, that feature alone is something I have to see. But, then in order to truly "see" it, I'll have to play through three or four times. And I just cannot get over the "KOTOR shooter" feeling asfar as the general game play, layout, camera, and a bunch of other stuff goes. As far as blending RPG and shooter, I think Borderlands done it better.
I'm replaying Castlevania: Symphony of the Night, for maybe the millionth time. I've thoroughly beat it inside and out, there is nothing about the game that I don't know, and I'd still pay for an HD graphics update the moment it's available if it ever happens. Unfortunately though it probably won't have the parts of the Japanese Saturn version, because it's a lot of fun playing as Maria.