take for example Haldane´s dilema:
Haldane's dilemma has not been solved - creation.com
I will paraphrase the dilemma with my own words,
Imagine a primitive ape that lived 5M years ago, this ape suffered from a genetic point mutation that was so positive that in just 100 years this mutation became fixed and dominant in the population. Then another ape (descendent of the first ape) has another positive mutation and in just 100 years the mutation becomes fixed and dominant.
Repeat this process for 5M years and you will end up having an ape with 50,000 positive mutations that were not present in the original ape.
Ok, so Humans and chimps have 3 Billion base pairs in their genome, if we are suppose to share 99% of our genome with them, then we have a difference of 30,000,000 base pairs.
But even under this unrealistic scenario (because we are assuming abundant “very positive mutations”) you can only account for 50,000 base pairs. You can account for less than the 0.002% of the changes that would be required in order to produce a human and an ape from a common ancestor who presumable lived 5M years ago and had a 1% genetic difference with relation to modern chimps and modern humans.
To me things are simple, there is obviously more than just random mutations + natural selection, there are obviously other mechanisms that produce big, fast and nonrandom changes.
This is an example of an absolute limit proposed by some creationists,