Well in order to evolve a worm-like creature in to a human you need bilions of mutations, each of them (or atleast most of them) has to be benefitial and selected by natural selection
Not trying to sound snooty, but how much experience do you have in genetics and related fields?
Seeing as how the genome of a worm (
C. elegans has about 20,000 protein coding genes, genome is about 100 million bps) and the genome of a human (also around 20,000 protein coding genes, genome is about 3 billion bps) are actually not that different (considering their phenotypes), the notion that "billions" of not just mutations, but beneficial mutations, had to have occurred to get a human from a worm is ludicrous.
Can you give an example of say successive 10 mutations that could have occured in the process of evolving a worm in to a human ? ..... I am not asking for a complete path. I am asking for .000000001% of the path sound reasonable?
Not at all reasonable, seeing as how according to your earlier claim, you expect that there should have been the equivalent of a complete replacement of the
C. elegans genome 30 times over to get a human, despite the fact that we have a similar number of genes.
Our genome is much larger than that of the worm
C. elegans, but we have similar number of genes (indicating that noncoding regulatory regions play an important role in phenotype). There are salamanders and ferns that have genomes many times larger than ours - so do not make the mistake of equating complexity with genome size. There largest currently known genome, after all, belongs to an amoeba (
P. dubia - about 67 BILLION bps).
In addition, while genome science is expanding at an incredible rate, finsing the specific sorets of mutations you demand, at this point, is roughly equivalent of me asking you to show me 10 of the grains of dust that Jehovah used to form Adam from.
Or provide some other evidence. Is there any robust evidence that shows that worm like creatures evolved in to humans by a proces of random mutations and natural selection?
You could peruse this site:
Tree of Life Web Project
In addition, I have posted this any times on another site I am active on, and sadly gotten very little in terms of scientific discourse from anti- evolutionists:
I forget now who originally posted these on this forum, but I keep it in my archives because it offers a nice 'linear' progression of testing a methodology and then applying it - I have posted this more than a dozen times for creationists who claim that there is no evidence for evolution:
The tested methodology:
Science 25 October 1991:
Vol. 254. no. 5031, pp. 554 - 558
Gene trees and the origins of inbred strains of mice
WR Atchley and WM Fitch
Extensive data on genetic divergence among 24 inbred strains of mice provide an opportunity to examine the concordance of gene trees and species trees, especially whether structured subsamples of loci give congruent estimates of phylogenetic relationships. Phylogenetic analyses of 144 separate loci reproduce almost exactly the known genealogical relationships among these 24 strains. Partitioning these loci into structured subsets representing loci coding for proteins, the immune system and endogenous viruses give incongruent phylogenetic results. The gene tree based on protein loci provides an accurate picture of the genealogical relationships among strains; however, gene trees based upon immune and viral data show significant deviations from known genealogical affinities.
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Science, Vol 255, Issue 5044, 589-592
Experimental phylogenetics: generation of a known phylogeny
DM Hillis, JJ Bull, ME White, MR Badgett, and IJ Molineux
Department of Zoology, University of Texas, Austin 78712.
Although methods of phylogenetic estimation are used routinely in comparative biology, direct tests of these methods are hampered by the lack of known phylogenies. Here a system based on serial propagation of bacteriophage T7 in the presence of a mutagen was used to create the first completely known phylogeny. Restriction-site maps of the terminal lineages were used to infer the evolutionary history of the experimental lines for comparison to the known history and actual ancestors. The five methods used to reconstruct branching pattern all predicted the correct topology but varied in their predictions of branch lengths; one method also predicts ancestral restriction maps and was found to be greater than 98 percent accurate.
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Science, Vol 264, Issue 5159, 671-677
Application and accuracy of molecular phylogenies
DM Hillis, JP Huelsenbeck, and CW Cunningham
Department of Zoology, University of Texas, Austin 78712.
Molecular investigations of evolutionary history are being used to study subjects as diverse as the epidemiology of acquired immune deficiency syndrome and the origin of life. These studies depend on accurate estimates of phylogeny. The performance of methods of phylogenetic analysis can be assessed by numerical simulation studies and by the experimental evolution of organisms in controlled laboratory situations. Both kinds of assessment indicate that existing methods are effective at estimating phylogenies over a wide range of evolutionary conditions, especially if information about substitution bias is used to provide differential weightings for character transformations.
We can hereby ASSUME that the results of an application of those methods have merit.
Application of the tested methodology:
Implications of natural selection in shaping 99.4% nonsynonymous DNA identity between humans and chimpanzees: Enlarging genus Homo
"Here we compare ≈90 kb of coding DNA nucleotide sequence from 97 human genes to their sequenced chimpanzee counterparts and to available sequenced gorilla, orangutan, and Old World monkey counterparts, and, on a more limited basis, to mouse. The nonsynonymous changes (functionally important), like synonymous changes (functionally much less important), show chimpanzees and humans to be most closely related, sharing 99.4% identity at nonsynonymous sites and 98.4% at synonymous sites. "
Mitochondrial Insertions into Primate Nuclear Genomes Suggest the Use of numts as a Tool for Phylogeny
"Moreover, numts identified in gorilla Supercontigs were used to test the human–chimp–gorilla trichotomy, yielding a high level of support for the sister relationship of human and chimpanzee."
A Molecular Phylogeny of Living Primates
"Once contentiously debated, the closest human relative of chimpanzee (Pan) within subfamily Homininae (Gorilla, Pan, Homo) is now generally undisputed. The branch forming the Homo andPanlineage apart from Gorilla is relatively short (node 73, 27 steps MP, 0 indels) compared with that of thePan genus (node 72, 91 steps MP, 2 indels) and suggests rapid speciation into the 3 genera occurred early in Homininae evolution. Based on 54 gene regions, Homo-Pan genetic distance range from 6.92 to 7.90×10−3 substitutions/site (P. paniscus and P. troglodytes, respectively), which is less than previous estimates based on large scale sequencing of specific regions such as chromosome 7[50]. "
That these methods have been tested on knowns, I find these powerful evidence in support of the big picture, evolution-wise.