wellwisher
Well-Known Member
Mutations begin as improper base pairing along the DNA. These improper base pairings are at higher potential than proper base pairing. Proper base pairings will form the optimum number of hydrogen bonds, thereby lowering potential. If you think in terms of equilibrium, if there was excess potential in the cell; stress, and thereby near the DNA, the improper base pairing, by being at higher potential may reflect a dynamic equilibrium. The excess potential in the cell may be an environmental stress and this stress is felt on the DNA, and becomes a structural attempt to balance the problem; defines the stress.Just wondering what scientists say makes - causes a mutation.
Cells have proofreader enzymes, whose job is to correct improper base pairs. They can tell where these flaws are by the extra potential that these typos have and emit into the water; finger print. However, the fact that the proof reader enzymes allow some typos to remain, or we would not have mutations, suggests that the cellular equilibrium or the need, is also felt by the proof readers, with an acceptance of this change consistent with a better story. One way for the proofreader to have its cake and eat it to, is leave the typo that formed on the changed strand, but alter the base on the complementary strand to the lower the overall potential. This lowers the potential while leaving a stable double change.