Humans incur between 100 and 200 mutations per individual per generation. I couldn't predict which person is going to get what mutation.Random and unpredictable are synonyms in my brain. I understand your point (I think) but it seems a touch pedantic.
However, there are some regions of the genome more susceptible to mutation and mutations that are immediately lethal.
I'm not sure I'm following, but if this regards directed mutation, that has not been demonstrated and what has been observed has been shown to be the results of selection.