These issues don't personally affect me, but after following the arguments and conflicts over the past decades I have developed a zoomed out view of this and other related issues. It is reasonable to review how Christian society treats people who are gay and people who think they are a different gender. It doesn't mean abandoning Christianity or abandoning the goals of Christ. "Give pain killers to those who are suffering" is how I interpret Proverbs 31:6 though its really about not getting high when you have a responsibility to perform. These people are hurting, and that is enough to cut them some slack.
Obviously there are political extremes. Those have to be reigned in, but extremes are how policy finds its way. Our society once had an extreme in which we punished homosexuals. That was an extreme, and we learned it was an extreme so that we could avoid that extreme.
Some people need special care, and we don't always know what to do. Its always going to be complicated. Its never going to be simple.
Circling back to your question about the 8 or the myriad genders: I don't think it affects me a lot. I think that we need to reign in some of the political extremes. I don't think we are going to lose our sense of what sex is or that people are going to stop being men and women, no matter what certain feminist movements (they aren't all the same) today may think. I don't think gender can be changed by society or reconstructed, but our understanding can be. Things are what they are, so lets be gracious. Perhaps someone can be treated with respect even if they don't perfectly conform to how we understand things. If political extremes result then its so that we can identify those and avoid them in the future.