Did you ever watch the 1983 movie Scarface, with Al Pacino? While Tony Montana (main character, played by Pacino) is having an argument with Frank Lopez, the guy he worked for, Montana retorts to Lopez's statement that he's giving him orders with this:
The point is that we live in a reality of pain & pleasure, and it doesn't make any difference what you want to call this reality (a computer simulation, a brain in a box or jar, a cave allegory type of situation, the Matrix, etc.); unless a person is self-destructive (for whatever reason), they're going to strive to achieve satisfaction and maximum pleasure, and minimize pain & suffering, or try to avoid these undesirable conditions altogether. Pain & pleasure exist and affect us, regardless of what kind of universe or reality we exist in.
Science is useful for making improvements to humanity that can and do provide more satisfaction and pleasure; for example, it helps to increase our access to food, which helps with satisfaction, by making it easier to produce more food to put on our plates with less effort. Same with roofs to go over our heads (i.e. shelter), including HVAC systems, lighting & power/energy for stoves, toasters, ovens, etc. Science is what has been very effective in being able to achieve much better access to these things than what our religious & superstitious ancestors tried to rely on hundreds or thousands of years ago.
Yes, science does also make us much more effective at creating weapons of war and destruction, but either way, we know that science gets results - good or bad.
Proving or disproving the existence of deities or fictional creatures that are obviously a gag or parody to make light of some of the obvious flaws with religion doesn't put food on my plate, or a roof over my head, or a source of energy for cooking my food or keeping it cold/refrigerated.