Why do you keep referencing "atheist scientists"? Do you think genetics is an atheistic exercise or something?
I'm going to assume that you both read and understood the paper you cited.
First, let's recap exactly what Alu repeats are. They are basically genetic parasites that replicate themselves in a host genome by "copy and paste", where they are transcribed into RNA and then made back into DNA and inserted back into the host genome.
So that they have function is hardly surprising, given that they are functional parasites to begin with. Also, because of the nature of their "life cycle", they can be a source of new genetic diversity, sometimes good but also sometimes bad (e.g., they've been linked to certain cancers and genetic diseases). For the most part however, they are fairly benign.
Now, let's note the following from the paper you cited...
"
Alu elements are the most prominent repeats in the human genome: they constitute more than 10% of the total DNA sequence in a cell and are present at up to 1.4 million copies per cell, and subfamilies of Alu elements share a 300-nucleotide consensus sequence of appreciable similarity."
So there are literally millions of Alu repeats in very human cell, which means that the discovery that some at times when one of them is pasted in a certain location, it affects function is 1) hardly surprising, and 2) not indicative that all 1.4 million copies therefore have the same fate.
Specifically from the paper....
"
We focused on mRNAs that contain a single 3′ UTR Alu element, to avoid the possibility of intramolecular base-pairing between inverted Alu elements, which could result in A-to-I editing and nuclear retention. Using the Antisense ncRNA Pipeline, we identified 378 lncRNAs that contain a single Alu element"
....which shows that we're talking about a small fraction of the overall population of Alu repeats.
So I'm not really sure just how you think this negates the use of Alu sequences in such things as paternity testing.
No, you're simply wrong. It's not just that humans share many of the same Alu sequences in the same locations as other primates, it's that when you survey primate genomes for these repeats, a clear and obvious pattern emerges that is entirely consistent with common ancestry.
Why do you keep referencing "atheist scientists"? Do you think genetics is an atheistic exercise or something?
I'm going to assume that you both read and understood the paper you cited.
First, let's recap exactly what Alu repeats are. They are basically genetic parasites that replicate themselves in a host genome by "copy and paste", where they are transcribed into RNA and then made back into DNA and inserted back into the host genome.
So that they have function is hardly surprising, given that they are functional parasites to begin with. Also, because of the nature of their "life cycle", they can be a source of new genetic diversity, sometimes good but also sometimes bad (e.g., they've been linked to certain cancers and genetic diseases). For the most part however, they are fairly benign.
Now, let's note the following from the paper you cited...
"
Alu elements are the most prominent repeats in the human genome: they constitute more than 10% of the total DNA sequence in a cell and are present at up to 1.4 million copies per cell, and subfamilies of Alu elements share a 300-nucleotide consensus sequence of appreciable similarity."
So there are literally millions of Alu repeats in very human cell, which means that the discovery that some at times when one of them is pasted in a certain location, it affects function is 1) hardly surprising, and 2) not indicative that all 1.4 million copies therefore have the same fate.
Specifically from the paper....
"
We focused on mRNAs that contain a single 3′ UTR Alu element, to avoid the possibility of intramolecular base-pairing between inverted Alu elements, which could result in A-to-I editing and nuclear retention. Using the Antisense ncRNA Pipeline, we identified 378 lncRNAs that contain a single Alu element"
....which shows that we're talking about a small fraction of the overall population of Alu repeats.
So I'm not really sure just how you think this negates the use of Alu sequences in such things as paternity testing.
No, you're simply wrong. It's not just that humans share many of the same Alu sequences in the same locations as other primates, it's that when you survey primate genomes for these repeats, a clear and obvious pattern emerges that is entirely consistent with common ancestry.
Comparative analysis of Alu repeats in primate genomes
From the paper....
"
Recent work increasingly recognizes that Alu elements have a greater impact than expected on phenotypic change, diseases, and evolution. Alu elements were demonstrated to mediate insertion mutagenesis, “exonization” by alternative splicing, genomic rearrangements, segmental duplication, and expression regulation causing disorders like Hunter syndrome, hemophilia A, and Sly syndrome (Batzer and Deininger 2002)."
So as you can see, your characterization of this work is just plain wrong.
??????? Are you saying that
Dr. Chenguang Gong and
Dr. Lynne Maquat are creationists?
Also, you didn't really answer my questions in my last post. If you're just going to do that, please say so and I won't bother.
From the paper....
"
Recent work increasingly recognizes that Alu elements have a greater impact than expected on phenotypic change, diseases, and evolution. Alu elements were demonstrated to mediate insertion mutagenesis, “exonization” by alternative splicing, genomic rearrangements, segmental duplication, and expression regulation causing disorders like Hunter syndrome, hemophilia A, and Sly syndrome (Batzer and Deininger 2002)."
So as you can see, your characterization of this work is just plain wrong.
??????? Are you saying that
Dr. Chenguang Gong and
Dr. Lynne Maquat are creationists?
Also, you didn't really answer my questions in my last post. If you're just going to do that, please say so and I won't bother.