Considering the distance between hydrogen atoms is on the order of a meter in interstellar space, I would say that most square decimeters are empty.
In any case, it is certainly a vacuum.
Dark Energy, Dark Matter | Science Mission Directorate'
One explanation for dark energy is that it is a property of space. Albert Einstein was the first person to realize that empty space is not nothing. Space has amazing properties, many of which are just beginning to be understood. The first property that Einstein discovered is that it is possible for more space to come into existence. Then one version of Einstein's gravity theory, the version that contains a cosmological constant, makes a second prediction: "empty space" can possess its own energy. Because this energy is a property of space itself, it would not be diluted as space expands. As more space comes into existence, more of this energy-of-space would appear. As a result, this form of energy would cause the universe to expand faster and faster. Unfortunately, no one understands why the cosmological constant should even be there, much less why it would have exactly the right value to cause the observed acceleration of the universe.
But it is an important mystery. It turns out that roughly 68% of the universe is dark energy. Dark matter makes up about 27%. The rest - everything on Earth, everything ever observed with all of our instruments, all normal matter - adds up to less than 5% of the universe.