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DNA Study Shows Why Neanderthals, Modern Humans Are So Different
"By Sharon Begley
NEW YORK (Reuters) - How can creatures as different in body and mind as present-day humans and their extinct Neanderthal cousins be 99.84 percent identical genetically?
Four years after scientists discovered that the two species' genomes differ by a fraction of a percent, geneticists said on Thursday they have an explanation: the cellular equivalent of "on"/"off" switches that determine whether DNA is activated or not.
Hundreds of Neanderthals' genes were turned off while the identical genes in today's humans are turned on, the international team announced in a paper published online in Science. They also found that hundreds of other genes were turned on in Neanderthals, but are off in people living today.
Among the hundreds: genes that control the shape of limbs and the function of the brain, traits where modern humans and Neanderthals differ most.
"People are fundamentally interested in what makes us human, in what makes us different from Neanderthals," said Sarah Tishkoff, an expert in human evolution at the University of Pennsylvania, who was not involved in the new study. Discovering the differences in gene activation is "an amazing technical feat," she said, and goes a long way to answering that riddle."
DNA Study Shows Why Neanderthals, Modern Humans Are So Different
DNA Study Shows Why Neanderthals, Modern Humans Are So Different
"By Sharon Begley
NEW YORK (Reuters) - How can creatures as different in body and mind as present-day humans and their extinct Neanderthal cousins be 99.84 percent identical genetically?
Four years after scientists discovered that the two species' genomes differ by a fraction of a percent, geneticists said on Thursday they have an explanation: the cellular equivalent of "on"/"off" switches that determine whether DNA is activated or not.
Hundreds of Neanderthals' genes were turned off while the identical genes in today's humans are turned on, the international team announced in a paper published online in Science. They also found that hundreds of other genes were turned on in Neanderthals, but are off in people living today.
Among the hundreds: genes that control the shape of limbs and the function of the brain, traits where modern humans and Neanderthals differ most.
"People are fundamentally interested in what makes us human, in what makes us different from Neanderthals," said Sarah Tishkoff, an expert in human evolution at the University of Pennsylvania, who was not involved in the new study. Discovering the differences in gene activation is "an amazing technical feat," she said, and goes a long way to answering that riddle."
DNA Study Shows Why Neanderthals, Modern Humans Are So Different