Safety and efficacy are the primary concerns when testing and approving new drugs. Shouldn't they be? That's why it takes so long to test potential new drugs and why so many don't end up ever being approved for human use.
In very general terms, safety and efficacy ought to be top considerations. But the whole determinations around safety is where I question the science, and noted in the post you quoted from. And the efficacy is perhaps the larger political debate playing out that I think is fairly well known for FDA having significant gaps in its scientific assertions.
With what I keep bringing up, it would I think be very challenging for anyone to look into what's going on with FDA and not see how much politics (of the nefarious kind) is influencing their determinations on safety and efficacy. Such that, to be as clear as I can, but am intentionally sticking to sound bites it is as follows:
- eCigs / vaping have no long term data on them, but do have a decent amount of anecdotal data, as well as a bunch of short term scientific studies. There is very low concern for issues regarding safety. Not no concern (for that would be not possible to find with any product), but very low. Their efficacy has shown, via lots of anecdotal data and some studies (further short term data) to be arguably the #1 product in history of regular tobacco products for reducing or eliminating a dependence on smoking. Which some scientists claim to be the #1 cause of preventable death in the U.S. (if not the world).
- Chantix is a pharmaceutical drug that is said to eliminate dependence on smoking. There is a decent amount of data to show it has catastrophic side effects, leading to numerous reported cases of people being suicidal, and a few cases of persons dying from suicide while taking Chantix. Then lots of other data with other behavioral issues in using the drug. But also it has shown to be effective in reducing the urge to smoke. But compared to short term studies of eCigs, it has a less effective rate. So, less safe (by far) and not quite as effective.
- But reality is that FDA cannot treat eCigs as a pharmaceutical product. In fact, they tried and were ruled by courts that they are not permitted to do so. But in April 2016, they have set up policy for eCigs such that all existing products must now jump through legal/bureaucratic hurdles that will amount to great reduction in what exists on the market and will benefit companies that have capital to stay in the market. The FDA (and other agencies like CDC) have either never suggested or very rarely suggested that eCigs are an effective tool in smoking cessation and do suggest a drug like Chantix is, with virtual denial around safety issues.
This is short version of all I could say. I would just add 2 things. One is that if one looks at what I've presented and investigate if FDA has ever done similar tactics with other products, it would be rather easy to determine yes they have. Fairly routinely. Such that a recent director of FDA is up for charges for inherent conflict of interest with pharmaceutical companies and ruling on products. Second is that between CDC and FDA, many of their scientific assertions are - if I'm speaking bluntly pseudo science. I actually would like to debate that with anyone, feeling confident that I'd either win such a debate or an opponent would reach a point of "agree to disagree" and choose to bow out. On eCigs stuff I feel around 90% confident in how the debate would go. But even with smoking data and science, I am around 50% confident I could win debates dealing with science and that product. Smoking is clearly a more uphill battle, but because of how FDA/CDC have manipulated (deceived) public on data they've presented, if one truly goes back and looks at source info around "harms of smoking," it is possible to see that the science is questionable and not really science. Or if it is science, it is the type of data that isn't really testable and is relying on a whole lot of leaps in logic to try to persuade people in a direction that observably many are currently in, but in my discussions/debates with those who hold to the narrative "smoking is inherently dangerous," I routinely see them show up as ignorant and underprepared for such a debate. I figure if I could win on the smoking debate, all other ones would be a cakewalk comparatively.
How else can we test these things, if we can't or won't use the scientific method? How does a philosophical approach help us determine whether drugs are effective or safe for human use?
Anecdotal evidence comes to mind. I wouldn't say only anecdotal and forget rigorous research from science, but would say the dual approach makes philosophical and policy sense going forward. Instead, it is truly as if the anecdotal is ruled out/dismissed in favor of idea that we don't have long term scientific data on the product and therefore "we don't know if it is safe or not."
Fortunately there are scientists involved in the debate who are at odds with FDA on this and at odds with federally funded anti-tobacco groups, which is leading to yet another battle among scientific minded people in modern affairs. But similar to say climate change debate, because one group of scientists are (well) funded by government while the other is funded through private organizations, then there's added nonsense in how this all appears politically. Anyone paying attention would see that national Democrats side with FDA on tobacco issue research and Pubs generally side with free market approach while including other scientific research.
From layperson perspective, it's partly framed as yet another aspect of partisan divide and how science appears to take sides on political matters, but is partly framed as how anecdotal evidence works in relation to scientific ideology.
Philosophically, which is partially to mainly my concern, the debate has yet to firmly establish what is meant by safety. Rather easy to note that no chemical / product (including water) is inherently and always safe. Thus when claims come about regarding 'potential harms / inherent dangers of vaping' - I do think it takes philosophical approach to actually understand what is being communicated, and how people/public is being deceived in a gross manner. Science apparently needs measurements of safety to be deemed viable, while philosophy would not necessary attack those measurements, but would focus on what makes for safety and will we put this in reasonable perspective of all other existing products?
And while I've said a whole bunch about vaping/eCigs/tobacco issues in this post, I do find the issue is bigger than this. It is huge deal politically (IMO) and is undermining science in way that I think few realize. And in a thread like this, it is partially how I filter things because I see the bias at work apart from what is attempting to be measured. It's partially that it needs to be measured before any so called reasonable determinations can be made and then what is it that needs to be measured, while pre-determining that this is 'best' item to be measured or sometimes framed as 'only thing' we can measure to lead us to a certain conclusion 'safety' or 'efficacy.'
I actually do think that because of manipulation occurring now that vaping could follow similar route to smoking, such that 20 years from now when long term data is in, it will already have 20 years of deception along the way to be a very tough battle to argue that it isn't "inherently dangerous." Philosophically (and spiritually) one could implement that tactic with arguably all phenomenon. But because of stigmatization it generally isn't the case. Though right about now, it is very challenging to find anything on the planet that doesn't have some group who takes an angle with a product / ideology which scrutinizes that as 'inherently dangerous.' Such that I can't honestly think of any ideology / thing that isn't scrutinized by someone and is isn't considered by at least someone as "inherently dangerous." If science enters that debate, it is mainly to measure how inherently dangerous is this. And given the right (political) funding, surely we can determine just how inherently dangerous it is and promote that to everyone. Well, unless we are instructed to cover it up. But if those private people try to expose our cover via the scientific method, we'll just use ad hom attacks to show they are inherently biased, probably greedy. Whereas, of course, our side is never like that. Heavens no.