Obviously, there are many differences between humans and other animals, just as there are between
any species and other animals. But if what's being sought is some qualitative difference, something that sets us apart from the animal kingdom, I don't think there's anything to be found, whether good or bad. Other animals do the "good" things that we think set up apart, like develop culture, create art, think, use tools, use language, etc. There are even species of insects that practice farming. And there are other animals who do the "bad" things we think set us apart, like kill for sport, engage in power struggles and violence, and practice selective infanticide. We're just one kind of animal with our own particular characteristics.
The traits that most set us apart are greater intelligence, bipedal locomotion, and opposable thumbs -- none of which are necessarily restricted to our species. These traits give us abilities that are dramatically advanced as compared to other animals. There are other animals, though, that dramatically outstrip us in fleetness of foot, swimming, climbing, physical strength, flight, reproductive capacity, and species viability.
We're a species that has so far lasted about 200,000 years, and it's entirely possible that we're nearer our end than our beginning. We're as vulnerable to a giant asteroid, for instance, as the dinosaurs were -- if we don't take ourselves out first. The descendants of the arthropods and cephalopods may well be around long after we're gone, and for sheer viability, there's probably nothing that can surpass the mighty bacteria.