Do you understand that the injecting the word "ultimately", changes the context of the statement.
It implies there are more ways then just the "ultimate" one to infuse meaning into things.
The word "ultimately" refers to things on a cosmic scale. If tomorrow an asteroid literally evaporates the planet, as in completely reduces it into rubble, all of us will be gone. And the universe at large, or even only our galactic corner, would remain virtually unchanged. We, our entire solar system, are insignificant on a cosmic scale. In fact, our entire galaxy is insignificant on a cosmic scale. There are literally billions upon billions of them.
But none of that changes that it's not meaningless while we are here.