Well, I can only say what's working for me. I've lost 36lbs in about 4 months, so it's working pretty well.
I'm not doing any fad diets or tricks or drinks or even Weight Watchers or the like. I'm simply monitoring my calorie intake and making sure I try to exercise on an, at least, somewhat regular basis.
First thing to do is to figure out what your basic caloric needs would be. Finding a calorie calculator is the easiest way to do this. Here's one I've used:
Calorie Calculator - Daily Caloric Needs
Once you know how many calories you need to maintain the weight you are now with the activity level you have, you can begin to figure how many calories to try to set your goal at. When limiting your calorie intake you will find that you will naturally end up eating healthier food as you simply cannot afford to eat the junk type food that has the higher calories. You'll simply never feel full and always feel hungry. Also, you may find that eating several small portions throughout the day helps you from feeling hungry at any given time instead of waiting for set mealtimes for larger meals. You'll tend to get hungry between those meals and be more susceptible to snacking.
I've found the best thing for me to do was get a couple small notebooks. One is where I log everything I eat, the calories, and my exercise for everyday. This helps to keep me on track and see what it is I'm doing and what I can adjust in my diet as I go. The other notebook is basically a journal. Where I track my highs and lows, my ideas, my weight loss, even my body measurements.
There are sites such as
Calorie Count which can help you find how many calories are in different things you eat.
Another thing to keep in mind is that weight loss isn't the most important thing when it comes to having a healthy body structure. Your body fat percentage has a lot to do with it. Here is a site to help determine what yours is:
Online Body Fat Percentage Calculator
Here are the charts to determine what those percentages mean:
Body Fat Percentage Charts for Men and Women
Again, these are the things which have helped me. No tricks, no fads, no special diet. Just watching what I eat, the calories, portion sizes and so on. It works well as long as you can stick to it. And really, once you've stuck to it a while it becomes easier and easier and almost second nature.