I'm sorry, but I'm still unclear on this. How do they interfere with mental balance and divorce our perception from our actual living experience? I honestly don't understand what you're getting at here.
Actually, I should thank you for asking. It is very difficult for me to understand how other people perceive the issue if they don't ask. For what it is worth, let me assure you that I see your questions as very respectful, if occasionally puzzling.
You see, for reasons difficult for me to pinpoint and not entirely healthy, personal responsibility is a value that is very close to the top in my worldview.
Our existence is a limited period of time during which we receive and cause impressions from the environment, including other people. During that time we go through a lot of uncertain situations and end up doing a lot of things that are not always wise, often enough without a true choice.
The end result is that we
will be unfair, unwise, destructive. All that is uncertain is to which degree, and how much we will try and manage to do to compensate that.
By this duty-oriented view of mine, the very idea of using psychoactives - substances that instead of allowing one to perceive reality as it is and adjusting or learning from it "get in the way" and force different perceptions, distorted or unrelated to the actual consensual reality - is by definition an obscenity.
I was shocked to (gradually) learn that not many people think so.