Hardy et al. cite the important recent work of Suzana Herculano-Houzel on primate brain scaling and number of neurons. In a series of studies, she and Karina Fonseca-Azevedo show brain growth among
Homo erectus could only have been achieved by way of the increased calories and glucose obtained from a cooked diet:
Metabolic constraint imposes tradeoff between body size and number of brain neurons in human evolution
Abstract
Despite a general trend for larger mammals to have larger brains, humans are the primates with the largest brain and number of neurons, but not the largest body mass. Why are great apes, the largest primates, not also those endowed with the largest brains? Recently, we showed that the energetic cost of the brain is a linear function of its numbers of neurons. Here we show that metabolic limitations that result from the number of hours available for feeding and the low caloric yield of raw foods impose a tradeoff between body size and number of brain neurons, which explains the small brain size of great apes compared with their large body size. This limitation was probably overcome in Homo erectus with the shift to a cooked diet. Absent the requirement to spend most available hours of the day feeding, the combination of newly freed time and a large number of brain neurons affordable on a cooked diet may thus have been a major positive driving force to the rapid increased in brain size in human evolution.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494886/
It only makes sense that the “major driving force to the rapid increase in brain size in human evolution” was the shift to a cooked diet, not meat-eating as speculated by some--if meat-eating were the factor that leads to brain development, then it would be carnivores, not humans, with the neuron-rich brains. Humans are not biologically adapted to meet their daily energy requirements by eating other animals; carnivores are. See Milton and Zucoloto below. Humans are not biologically adapted to catch and kill other animals of any significant size without great expenditures of energy. What distinguishes early
Homo from all other animals is not eating meat but cooking food.
The following is from Herculano-Houzel’s 2012 study published in June prior to the November 2012 publication:
It can thus be seen how any increase in total numbers of neurons in the evolution of hominins and great apes would have taxed survival in a limiting, if not prohibitive, way, given that it probably would have to occur in a context of already limiting feeding hours: The added 60 billion brain neurons from an orangutan-sized hominin ancestor to modern Homo require an additional 360 kcal/d, which is probably not readily available to great apes on their diet.
It has been proposed that the advent of the ability to control fire to cook foods, which increases enormously the energy yield of foods and the speed with which they are consumed (92, 93), may have been a crucial step in allowing the near doubling of numbers of brain neurons that is estimated to have occurred between H. erectus and H. sapiens (94). The evolution of the human brain, with its high metabolic cost imposed by its large number of neurons, may thus only have been possible because of the use of fire to cook foods, enabling individuals to ingest in very little time the entire caloric requirement for the day, and thereby freeing time to use the added neurons to their competitive advantage.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386878/
In a letter published in
American Journal of Clinical Nutrition in 2000, Katharine Milton pointed out:
The technologic abilities of humans derive from their unusually large, complex brain, a brain that, under normal conditions, is fueled by a steady supply of glucose. Consumption of digestible carbohydrate is the most efficient way for humans to obtain glucose for brain function. Potential alternatives--gluconeogenesis or the use of ketones to fuel the brain--represent alternative, more costly metabolic solutions.
http://ajcn.nutrition.org/content/72/6/1590.full
Zucoloto’s 2011 review in
Psychology and Neuroscience provides further details:
Evolution of the human feeding behavior
The human species is not adapted to the consumption of large amounts of animal (i.e., protein-rich) feeding sources to meet their energy needs because serious renal and hepatic problems can occur from high neoglucogenesis. Proteins are formed by amino acids that have, as their basic structure, the chemical elements carbon, hydrogen, oxygen, and nitrogen, with some exceptions, such as the insect chitin. To liberate energy, the organism uses carbohydrates and lipids. If they lack these substances, then they use amino acids. To utilize amino acids as an energy source, the organism must remove nitrogen through a process known as deamination. Thus, an amino acid molecule without nitrogen atoms can be metabolized or transformed into glucose and metabolize. In the human species, this metabolic process, known as neoglucogenesis, occurs in the liver, and the excess nitrogen must be excreted. This causes a work overload, which can seriously affect the liver and kidneys (Sackheim & Lehman, 2001).
http://psycnet.apa.org/journals/pne/4/1/131.html
In Milton’s 1999 paper, after noting the variety of ways that humans are biologically distinguished from carnivores, she discusses some of the known detrimental effects of high-protein diets on non-carnivores. Ultimately she points out that “adult humans apparently cannot catabolize sufficient protein to meet more than 50% of the daily energetic requirements.”