If a religion makes claims that are provably false, then it is not right in these claims. Perhaps there is no good reason to accept anything they say in this case.
I prefer to first focus on the question of whether or not the claims are true. I don't consider this to be negative. Anytime someone tells me something or I read something in the news, I first want to validate it's truth. Why believe and act on something untrue?
Worldviews do a better or worse job of conforming to reality. It's a philosophical question of whether a worldview can be justified via critical thinking based on true facts.
I think of it in terms of whether the teachings and doctrines are true or not. Why defend something that is untrue, no matter what it's domain, religious, political, cultural, pseudo-scientific, pseudo-philosophical.
Even talking to yourself to plan what you want to do with your day "works".
I think of prayer in terms of communicating with supernatural beings who change reality as a response. Since I don't believe in such a thing, I don't believe prayer exists except as the ritual of doing it.
If sin is defined as actions that displease God or in disobedience to God, then, there is no such thing as sin. There can be repentance for the things we have done that harm others.